PMID- 38164493
OWN - NLM
STAT- MEDLINE
DCOM- 20240103
LR  - 20240304
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Correlation of renal function indicators and vascular damage in T2DM patients 
      with normal renal function.
PG  - 1292397
LID - 10.3389/fendo.2023.1292397 [doi]
LID - 1292397
AB  - BACKGROUND: This study aimed to assess the correlation between renal 
      function-related indices and vascular damages among patients with type 2 diabetes 
      mellitus (T2DM) and normal renal function. METHODS: We screened a cohort of 
      eligible patients with T2DM, ultimately including 826 individuals. Utilizing 
      multifactorial logistic regression, we conducted an in-depth analysis to explore 
      the potential associations between renal function-related indices-specifically 
      BUN, Cr, ALB, ACR, and eGFR-and the incidence of diabetic vascular damage. 
      Additionally, to comprehensively understand the relationships, we employed 
      Spearman correlation analysis to assess the connections between these indicators 
      and the occurrence of vascular damage. RESULTS: In this cross-sectional study of 
      532 patients with carotid atherosclerosis (CA), the prevalence of CA was 
      positively correlated with Cr (53.1%, 72.3%, 68.0%, P<0.05) and negatively 
      correlated with eGFR (71.6%, 68.5%, 53.1%, P<0.05). the higher the Cr, the higher 
      the predominance ratio of CA (T1: reference; T2:OR. 2.166,95%CI:1.454,3.225; 
      T3:OR:1.677, 95%CI:1.075, 2.616; P<0.05), along with an eGFR of 66.9% and 52.0% 
      in terms of sensitivity and specificity, with a 95% CI of 0.562-0.644. 
      CONCLUSION: Within our experimental sample, a noteworthy observation emerged: 
      Creatinine (Cr) exhibited a positive correlation with the prevalence of 
      individuals affected by carotid atherosclerosis (CA), underscoring a potential 
      connection between Cr levels and CA incidence. Conversely, the estimated 
      Glomerular Filtration Rate (eGFR) demonstrated a negative correlation with the 
      occurrence of CA, implying that lower eGFR values might be associated with an 
      increased likelihood of CA development.
CI  - Copyright (c) 2023 Zhang, Gui, Chen and Wan.
FAU - Zhang, Yue-Yang
AU  - Zhang YY
AD  - Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest 
      Medical University, Luzhou, China.
AD  - Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
AD  - Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, China.
AD  - Sichuan Clinical Research Center for Nephropathy, Luzhou, China.
AD  - Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, China.
FAU - Gui, Jing
AU  - Gui J
AD  - Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest 
      Medical University, Luzhou, China.
AD  - Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
AD  - Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, China.
AD  - Sichuan Clinical Research Center for Nephropathy, Luzhou, China.
AD  - Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, China.
FAU - Chen, Bing-Xue
AU  - Chen BX
AD  - Department of Medical Imaging, Southwest Medical University, Luzhou, China.
FAU - Wan, Qin
AU  - Wan Q
AD  - Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest 
      Medical University, Luzhou, China.
AD  - Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
AD  - Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, China.
AD  - Sichuan Clinical Research Center for Nephropathy, Luzhou, China.
AD  - Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231218
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Cross-Sectional Studies
MH  - Glomerular Filtration Rate
MH  - *Carotid Artery Diseases/complications
MH  - Kidney
PMC - PMC10758123
OTO - NOTNLM
OT  - Cr
OT  - carotid atherosclerosis
OT  - eGFR
OT  - renal function
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/02 11:46
MHDA- 2024/01/03 09:43
PMCR- 2023/01/01
CRDT- 2024/01/02 03:46
PHST- 2023/09/11 00:00 [received]
PHST- 2023/11/27 00:00 [accepted]
PHST- 2024/01/03 09:43 [medline]
PHST- 2024/01/02 11:46 [pubmed]
PHST- 2024/01/02 03:46 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1292397 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Dec 18;14:1292397. doi: 
      10.3389/fendo.2023.1292397. eCollection 2023.