PMID- 38164502
OWN - NLM
STAT- MEDLINE
DCOM- 20240103
LR  - 20240205
IS  - 2206-7418 (Electronic)
IS  - 2206-7418 (Linking)
VI  - 8
IP  - 1
DP  - 2024
TI  - Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic 
      Imaging and Photothermal Therapy of Tumors.
PG  - 100-111
LID - 10.7150/ntno.88892 [doi]
AB  - Background: Phthalocyanine (PC) and naphthalocyanine (NC) dyes have long garnered 
      interest as theranostic agents for optical imaging and phototherapy due to their 
      near-infrared absorbance, photostability, imaging contrast, and proven safety in 
      clinical trials. Yet, only a small fraction of these dyes has been evaluated as 
      photothermal therapy (PTT) agents for cancer treatment. Methods: Nearly 40 
      distinct NC and PC dyes were encapsulated within polymeric PEG-PCL micelles via 
      oil-in-water emulsions. The optimal NC/PC-loaded micelle formulations for PTT and 
      photoacoustic (PA) imaging were identified through in vivo and in vitro studies. 
      Results: The most promising candidate, CuNC(Octa)-loaded micelles, demonstrated a 
      strong PA signal with a peak absorbance at ~870 nm, high photothermal efficiency, 
      and photostability. The CuNC(Octa)-loaded micelles exhibited heat generation as 
      good or better than gold nanorods/nanoshells and >10-fold higher photoacoustic 
      signals. Micelle preparation was reproducible/scalable, and the CuNC(Octa)-loaded 
      micelles are highly stable under physiological conditions. The CuNC(Octa)-loaded 
      micelles localize within tumors via enhanced permeability and retention and are 
      readily detectable by PA imaging. In a syngeneic murine tumor model of 
      triple-negative breast cancer, CuNC(Octa)-loaded micelles demonstrate efficient 
      heat generation with PTT, leading to the complete eradication of tumors. 
      Conclusions: CuNC(Octa)-loaded micelles represent a promising theranostic agent 
      for PA imaging and PTT. The ability to utilize conventional ultrasound in 
      combination with PA imaging enables the simultaneous acquisition of information 
      about tumor morphology and micelle accumulation. PTT with CuNC(Octa)-loaded 
      micelles can lead to the complete eradication of highly invasive tumors.
CI  - (c) The author(s).
FAU - Tian, Yiran
AU  - Tian Y
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
FAU - Carrillo-Malani, Nicole
AU  - Carrillo-Malani N
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
FAU - Feng, Kailin
AU  - Feng K
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
FAU - Miller, Joann
AU  - Miller J
AD  - Department of Radiation Oncology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA, 19104, USA.
FAU - Busch, Theresa M
AU  - Busch TM
AD  - Department of Radiation Oncology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA, 19104, USA.
FAU - Sundaram, Karthik M
AU  - Sundaram KM
AD  - Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA 
      19104, USA.
FAU - Cheng, Zhiliang
AU  - Cheng Z
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
FAU - Amirshaghaghi, Ahmad
AU  - Amirshaghaghi A
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
FAU - Tsourkas, Andrew
AU  - Tsourkas A
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
LA  - eng
GR  - R01 EB028858/EB/NIBIB NIH HHS/United States
GR  - R01 EB029238/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20240101
PL  - Australia
TA  - Nanotheranostics
JT  - Nanotheranostics
JID - 101698994
RN  - V5PUF4VLGY (phthalocyanine)
RN  - 0 (Micelles)
RN  - 0 (Indoles)
RN  - 0 (Coloring Agents)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Micelles
MH  - Photothermal Therapy
MH  - Precision Medicine
MH  - *Photoacoustic Techniques/methods
MH  - *Nanoparticles/therapeutic use
MH  - Indoles
MH  - Coloring Agents/therapeutic use
MH  - *Neoplasms/therapy/drug therapy
PMC - PMC10750118
OTO - NOTNLM
OT  - naphthalocyanine
OT  - photoacoustic imaging
OT  - photothermal therapy
OT  - phthalocyanine
OT  - theranostic
COIS- Competing Interests: TMB reports other support from Simphotek and personal fees 
      from Lumeda and IBA outside the submitted work.
EDAT- 2024/01/02 11:43
MHDA- 2024/01/03 09:43
PMCR- 2024/01/01
CRDT- 2024/01/02 03:46
PHST- 2023/08/10 00:00 [received]
PHST- 2023/11/02 00:00 [accepted]
PHST- 2024/01/03 09:43 [medline]
PHST- 2024/01/02 11:43 [pubmed]
PHST- 2024/01/02 03:46 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - ntnov08p0100 [pii]
AID - 10.7150/ntno.88892 [doi]
PST - epublish
SO  - Nanotheranostics. 2024 Jan 1;8(1):100-111. doi: 10.7150/ntno.88892. eCollection 
      2024.