PMID- 38166066
OWN - NLM
STAT- MEDLINE
DCOM- 20240104
LR  - 20240105
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 19
IP  - 1
DP  - 2024
TI  - Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A 
      population-based cohort study in Denmark.
PG  - e0296434
LID - 10.1371/journal.pone.0296434 [doi]
LID - e0296434
AB  - BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is related to developing lung 
      and liver disease, but no large-scale studies examine its association with birth 
      outcomes. OBJECTIVE: We investigated the risk of pregnancy complications and 
      adverse birth outcomes in mothers and children with AATD. METHODS: Using a large 
      cohort data of Danish mothers and children with AATD from 1973 to 2013 (n = 
      2,027,229), with 559 cases (305 mothers and 254 children). We conducted Poisson 
      regression to examine associations between alpha-1 antitrypsin deficiency, 
      adverse birth outcomes, and pregnancy complications in mothers and children. 
      RESULTS: AATD was related to term low birth weight [<2500g; Risk Ratio(RR) = 
      2.04, 95% confidence interval (CI): 1.50-2.79], lowest quartile of abdominal 
      circumference at birth in children of non-smoking mothers (RR = 1.55, 95% CI: 
      1.14-2.11), delivery via Cesarean-section (RR = 1.59, 95% CI: 1.05-2.40), preterm 
      birth (RR = 1.54, 95% CI: 1.19-2.00) and preeclampsia (RR = 2.64, 95% CI: 
      1.76-3.94). CONCLUSIONS: This emphasizes the need for mothers with AATD to be 
      monitored closely during pregnancy to reduce the risk of adverse birth outcomes. 
      Routine screening for alpha-1 antitrypsin in pregnancy may be considered among 
      mothers with a pulmonary and liver disease history.
CI  - Copyright: (c) 2024 Orimoloye et al. This is an open access article distributed 
      under the terms of the Creative Commons Attribution License, which permits 
      unrestricted use, distribution, and reproduction in any medium, provided the 
      original author and source are credited.
FAU - Orimoloye, Helen T
AU  - Orimoloye HT
AUID- ORCID: 0000-0002-3895-3363
AD  - Department of Rehabilitation and Health Services, University of North Texas, 
      Denton, Texas, United States of America.
FAU - He, Di
AU  - He D
AUID- ORCID: 0000-0002-3589-4484
AD  - Department of Epidemiology, Fielding School of Public Health, University of 
      California, Los Angeles, Los Angeles, California, United States of America.
FAU - Li, Tong
AU  - Li T
AD  - Department of Epidemiology, Fielding School of Public Health, University of 
      California, Los Angeles, Los Angeles, California, United States of America.
FAU - Janzen, Carla
AU  - Janzen C
AD  - Department of Obstetrics and Gynecology, University of California, Los Angeles, 
      Los Angeles, California, United States of America.
FAU - Barjaktarevic, Igor
AU  - Barjaktarevic I
AD  - Division of Pulmonary and Critical Care, University of California, Los Angeles, 
      Los Angeles, California, United States of America.
FAU - Wang, Xuexia
AU  - Wang X
AD  - Department of Biostatistics, Florida International University, Miami, Florida, 
      United States of America.
FAU - Hansen, Johnni
AU  - Hansen J
AD  - Danish Cancer Society, Copenhagen, Denmark.
FAU - Heck, Julia E
AU  - Heck JE
AUID- ORCID: 0000-0001-8713-8413
AD  - Department of Rehabilitation and Health Services, University of North Texas, 
      Denton, Texas, United States of America.
AD  - Department of Epidemiology, Fielding School of Public Health, University of 
      California, Los Angeles, Los Angeles, California, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20240102
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - alpha 1-Antitrypsin
MH  - *alpha 1-Antitrypsin Deficiency/complications/epidemiology/diagnosis
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - *Pregnancy Complications/epidemiology
MH  - *Premature Birth
PMC - PMC10760838
COIS- Dr. Barjaktarevic has received consulting fees from Grifols unrelated to the 
      current project. This does not alter our adherence to all PLOS ONE policies on 
      sharing data and materials.
EDAT- 2024/01/03 09:44
MHDA- 2024/01/04 11:44
PMCR- 2024/01/02
CRDT- 2024/01/02 14:07
PHST- 2023/04/19 00:00 [received]
PHST- 2023/12/13 00:00 [accepted]
PHST- 2024/01/04 11:44 [medline]
PHST- 2024/01/03 09:44 [pubmed]
PHST- 2024/01/02 14:07 [entrez]
PHST- 2024/01/02 00:00 [pmc-release]
AID - PONE-D-23-11227 [pii]
AID - 10.1371/journal.pone.0296434 [doi]
PST - epublish
SO  - PLoS One. 2024 Jan 2;19(1):e0296434. doi: 10.1371/journal.pone.0296434. 
      eCollection 2024.