PMID- 38166697
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240106
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Jan 2
TI  - Effect of trace element mixtures on the outcome of patients with esophageal 
      squamous cell carcinoma: a prospective cohort study in Fujian, China.
PG  - 24
LID - 10.1186/s12885-023-11763-9 [doi]
LID - 24
AB  - BACKGROUND: The evidence about the effects of trace elements on overall 
      survival(OS) of patients with esophageal squamous cell carcinoma(ESCC) is 
      limited. This study aims to evaluate mixed effects of plasma trace elements on OS 
      of ESCC. METHODS: This prospective cohort analysis included 497 ESCC patients 
      with a median follow-up of 52.3 months. The concentrations of 17 trace elements 
      were measured. We fitted Cox's proportional hazards regression, factor analysis 
      and Bayesian kernel machine regression (BKMR) models to estimate the association 
      between trace elements and OS. RESULTS: Our analysis found that in the 
      single-element model, Co, Ni, and Cd were associated with an increased risk of 
      death, while Ga, Rb, and Ba were associated with a decreased risk. Cd had the 
      strongest risk effect among all elements. As many elements were found to be 
      mutually correlated, we conducted a factor analysis to identify common factors 
      and investigate their associations with survival time. The factor analysis 
      indicated that the factor with high factor loadings in Ga, Ba and B was linked to 
      a decreased risk of death, while the factor with high factor loadings in Co, Ti, 
      Cd and Pb was associated with a borderline significantly increased risk. Using 
      BKMR analysis to disentangle the interaction between elements in significant 
      factors, we discovered that Ga interacted with Ba and both elements had U-shaped 
      effects with OS. Cd, on the other hand, had no interaction with other elements 
      and independently increased the risk of death. CONCLUSIONS: Our analysis revealed 
      that Ga, Ba and Cd were associated with ESCC outcome, with Ga and Ba 
      demonstrating an interaction. These findings provide new insights into the impact 
      of trace elements on the survival of patients with ESCC.
CI  - (c) 2023. The Author(s).
FAU - Yu, Kaili
AU  - Yu K
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Liu, Shuang
AU  - Liu S
AD  - Sun Yat-Sen University Cancer Center/Cancer Hospital, Guangzhou, 510060, China.
FAU - Lin, Zheng
AU  - Lin Z
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Song, Jianyu
AU  - Song J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Zeng, Qiaoyan
AU  - Zeng Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Zhou, Jinsong
AU  - Zhou J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Zhang, Juwei
AU  - Zhang J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Zhang, Suhong
AU  - Zhang S
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China.
FAU - Lin, Jianbo
AU  - Lin J
AD  - The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, 
      Fujian, China.
FAU - Xiang, Zhisheng
AU  - Xiang Z
AD  - Fujian Cancer Hospital, Fuzhou, 350014, Fujian, China.
FAU - Hu, Zhijian
AU  - Hu Z
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, Fujian, China. huzhijian@fjmu.edu.cn.
AD  - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian 
      Medical University, FuZhou, 350122, Fujian, China. huzhijian@fjmu.edu.cn.
LA  - eng
GR  - 2020Y9018/Scientific and Technological Innovation Joint Capital Projects of 
      Fujian Province/
GR  - 2021J01726/Natural Science Foundation of Fujian Province/
GR  - 2020L3009/Central government-led local science and technology development special 
      project/
GR  - 2019L3006/Grant of Science and Technology of Fujian, China/
PT  - Journal Article
DEP - 20240102
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - 0 (Trace Elements)
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Humans
MH  - *Esophageal Squamous Cell Carcinoma
MH  - *Trace Elements
MH  - Prospective Studies
MH  - *Esophageal Neoplasms
MH  - Bayes Theorem
MH  - Cadmium
MH  - Cohort Studies
PMC - PMC10762846
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Esophageal squamous cell carcinoma
OT  - Outcome
OT  - Trace elements
COIS- The authors declare no competing interests.
EDAT- 2024/01/04 01:18
MHDA- 2024/01/05 06:42
PMCR- 2024/01/02
CRDT- 2024/01/03 09:10
PHST- 2023/03/14 00:00 [received]
PHST- 2023/12/14 00:00 [accepted]
PHST- 2024/01/05 06:42 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 09:10 [entrez]
PHST- 2024/01/02 00:00 [pmc-release]
AID - 10.1186/s12885-023-11763-9 [pii]
AID - 11763 [pii]
AID - 10.1186/s12885-023-11763-9 [doi]
PST - epublish
SO  - BMC Cancer. 2024 Jan 2;24(1):24. doi: 10.1186/s12885-023-11763-9.