PMID- 38167163
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240106
IS  - 2047-783X (Electronic)
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 29
IP  - 1
DP  - 2024 Jan 2
TI  - The association between blood lipids and cognitive impairment in type 2 diabetes 
      mellitus.
PG  - 1
LID - 10.1186/s40001-023-01574-w [doi]
LID - 1
AB  - OBJECTIVE: The study was performed to explore the association between blood 
      lipids and cognitive impairment in patients with type 2 diabetes mellitus (T2DM). 
      METHODS: This study included 336 patients with T2DM. Relevant clinical data 
      including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), 
      low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein 
      A1, apolipoprotein B were collected, and the Mini-Mental State Examination (MMSE) 
      score and Montreal Cognitive Assessment (MoCA) score were used to assess the 
      cognitive function in patients with T2DM. RESULTS: Serum apolipoprotein A1 levels 
      were significantly increased in T2DM patients with cognitive impairment compared 
      with T2DM patients without cognitive impairment (p = 0.017). Serum apolipoprotein 
      A1 levels were significantly negatively correlated with MoCA score (r = - 0.143, 
      p = 0.009) and MMSE score (r = - 0.132, p = 0.016) in patients with T2DM. In 
      multivariable-adjusted regression model, serum apolipoprotein A1 was 
      independently associated with cognitive impairment in patients with T2DM 
      (OR = 5.201, p = 0.024). CONCLUSION: Serum apolipoprotein A1 is associated with 
      cognitive impairment in patients with T2DM, but not TC, TG, HDL-C, LDL-C, and 
      apolipoprotein B, indicating that increased serum apolipoprotein A1 may be a risk 
      factor of cognitive impairment in patients with T2DM.
CI  - (c) 2023. The Author(s).
FAU - Ma, Li
AU  - Ma L
AD  - Department of Rehabilitative Medicine, Affiliated Zhongda Hospital of Southeast 
      University, Nanjing, 210009, Jiangsu, China.
FAU - Yuan, Yue-Xing
AU  - Yuan YX
AD  - Department of Endocrinology and Metabolism, Affiliated Zhongda Hospital of 
      Southeast University, Nanjing, 210009, Jiangsu, China.
FAU - Cheng, Feng-Jin
AU  - Cheng FJ
AD  - Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, 210009, Jiangsu, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast 
      University, Nanjing, 210009, Jiangsu, China.
FAU - Wei, Qiong
AU  - Wei Q
AD  - Department of Endocrinology and Metabolism, Affiliated Zhongda Hospital of 
      Southeast University, Nanjing, 210009, Jiangsu, China. weiqiong_seu@163.com.
FAU - Peng, You-Fan
AU  - Peng YF
AD  - Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of 
      Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China. 
      youfanpeng@hotmail.com.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Endocrinology and Metabolism, Affiliated Zhongda Hospital of 
      Southeast University, Nanjing, 210009, Jiangsu, China. wang_yao100@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240102
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Apolipoprotein A-I
MH  - Cholesterol, LDL
MH  - Lipids
MH  - Triglycerides
MH  - Cholesterol, HDL
MH  - *Cognitive Dysfunction/complications
PMC - PMC10763275
OTO - NOTNLM
OT  - Blood lipids
OT  - Cognitive impairment
OT  - Type 2 diabetes mellitus
COIS- All authors have no interests of a financial or personal nature to declare.
EDAT- 2024/01/04 01:18
MHDA- 2024/01/05 06:42
PMCR- 2024/01/02
CRDT- 2024/01/03 09:35
PHST- 2023/08/16 00:00 [received]
PHST- 2023/12/07 00:00 [accepted]
PHST- 2024/01/05 06:42 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 09:35 [entrez]
PHST- 2024/01/02 00:00 [pmc-release]
AID - 10.1186/s40001-023-01574-w [pii]
AID - 1574 [pii]
AID - 10.1186/s40001-023-01574-w [doi]
PST - epublish
SO  - Eur J Med Res. 2024 Jan 2;29(1):1. doi: 10.1186/s40001-023-01574-w.