PMID- 38167312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240105
IS  - 2332-8886 (Electronic)
IS  - 2332-8886 (Linking)
VI  - 10
IP  - 1
DP  - 2024 Jan 3
TI  - Beyond pediatrics: noninvasive spinal neuromodulation improves motor function in 
      an adult with cerebral palsy.
PG  - 1
LID - 10.1186/s42234-023-00133-2 [doi]
LID - 1
AB  - Regaining motor function in individuals with cerebral palsy (CP) has been 
      predominantly studied in children, resulting in an underrepresentation of adults 
      in research efforts. We tested the efficacy of noninvasive spinal neuromodulation 
      with neurorehabilitation (Spinal Cord Innovation in Pediatrics; SCiP therapy). A 
      60-year-old CP participant underwent 8 weeks of SCiP therapy, resulting in 
      significant motor recovery measured by 14.2-points increase in gross motor 
      function measure (GMFM-88) score, ~ three times the Minimal Clinically Important 
      Difference (MCID) of 5-points. This represented gains in kneeling, sitting, and 
      walking functions. The improvement in GMFM-88 score was maintained above the MCID 
      at the follow up visit (10.3 points above the baseline), twenty weeks following 
      the last therapy session, indicating a persistent effect of the therapy. Our 
      preliminary findings support the therapeutic promise of SCiP therapy for 
      enhancing motor function in CP adults. Broader investigations are needed to 
      establish its wider applicability.
CI  - (c) 2023. The Author(s).
FAU - Sachdeva, Rahul
AU  - Sachdeva R
AUID- ORCID: 0000-0001-7972-9344
AD  - SpineX Inc, Los Angeles, CA, 91324, USA. rahulsachdeva08@gmail.com.
AD  - Department of Medicine, International Collaboration On Repair Discoveries 
      (ICORD), University of British Columbia, Vancouver, BC, V5Z1M9, Canada. 
      rahulsachdeva08@gmail.com.
FAU - Girshin, Kristin
AU  - Girshin K
AD  - SpineX Inc, Los Angeles, CA, 91324, USA.
AD  - GirshinPT Rancho, Cucamunga, CA, 91701, USA.
FAU - Shirkhani, Yousef
AU  - Shirkhani Y
AD  - GirshinPT Rancho, Cucamunga, CA, 91701, USA.
FAU - Gad, Parag
AU  - Gad P
AD  - SpineX Inc, Los Angeles, CA, 91324, USA.
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - England
TA  - Bioelectron Med
JT  - Bioelectronic medicine
JID - 101660849
PMC - PMC10762938
OTO - NOTNLM
OT  - Cerebral Palsy
OT  - Noninvasive Stimulation
OT  - Sensorimotor Function
OT  - Spinal Cord Neuromodulation
COIS- Parag Gad has Shareholder interest in SpineX Inc.
EDAT- 2024/01/04 01:18
MHDA- 2024/01/04 01:19
PMCR- 2024/01/03
CRDT- 2024/01/03 09:44
PHST- 2023/10/04 00:00 [received]
PHST- 2023/11/09 00:00 [accepted]
PHST- 2024/01/04 01:19 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 09:44 [entrez]
PHST- 2024/01/03 00:00 [pmc-release]
AID - 10.1186/s42234-023-00133-2 [pii]
AID - 133 [pii]
AID - 10.1186/s42234-023-00133-2 [doi]
PST - epublish
SO  - Bioelectron Med. 2024 Jan 3;10(1):1. doi: 10.1186/s42234-023-00133-2.