PMID- 38168059
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1735-546X (Electronic)
IS  - 1735-1308 (Linking)
VI  - 21
IP  - 2
DP  - 2024 Mar 24
TI  - Multiple Fluorescences in Situ Hybridization Status in Excreted Urine Improve 
      Diagnostic Efficacy for Upper Urinary Tract Urothelial Carcinomas.
PG  - 107-113
LID - 10.22037/uj.v20i.7973 [doi]
AB  - PURPOSE: To evaluate the diagnostic accuracy of single and multiple fluorescence 
      in situ hybridization (FISH) tests for upper urinary tract cancer (UTUC), we 
      analyzed the diagnostic efficacy of FISH in patients with UTUC and the difference 
      between it and the Tumor Node Metastasis (TNM) stage and grade of the tumor. 
      MATERIALS AND METHODS: Patients treated for UTUC at our institution between 2011 
      and 2021 who had not been previously diagnosed with UTUC were included. Patients 
      were divided into single, two, and multiple (three times or four times) FISH 
      groups based on the number of FISH tests performed on different samples from the 
      same patient, and the diagnostic efficiency of single, two, and multiple FISH 
      tests for muscle-invasive tumors and highgrade tumors were assessed. RESULTS: We 
      included a total of 207 patients with UTUC, and when compared to single FISH, the 
      sensitivity of multiple and double FISH for the diagnosis of UTUC increased from 
      62% to 76% and 78%, respectively. It went from 67% to 78% and 80% for 
      muscle-invasive UTUC (> = pT2) and from 71% to 79% and 81% for the highest- grade 
      UTUC. CONCLUSION: Multiple FISH improves the diagnostic efficacy of UTUC and 
      helps to differentiate aggressive tumors.
FAU - Tang, Feng
AU  - Tang F
AD  - Jingzhou Central Hospital, Jingzhou, Jingzhou Hospital Affiliated to Yangtze 
      University, Hubei, China. tangfeng0013@163.com.
FAU - Wang, Xia
AU  - Wang X
AD  - Department of Public Health, Wuhan University Hospital, Wuhan University, Wuhan, 
      China. wxask1981@126.com.
FAU - Liu, Tao
AU  - Liu T
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      liutaozaiwuda@whu.edu.cn.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      1269267573@qq.com.
FAU - Wan, Ziyu
AU  - Wan Z
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      592135672@qq.com.
FAU - Fu, Qiqi
AU  - Fu Q
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      fqq15279210670@163.com.
FAU - Zheng, Zhangjie
AU  - Zheng Z
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      3093883488@qq.com.
FAU - Aersi, Madanyeti
AU  - Aersi M
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      2674665643@qq.com.
FAU - Peng, Jianping
AU  - Peng J
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. 
      pengjianping@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240324
PL  - Iran
TA  - Urol J
JT  - Urology journal
JID - 101286676
SB  - IM
MH  - Humans
MH  - *Carcinoma, Transitional Cell/diagnosis/pathology
MH  - *Urinary Bladder Neoplasms/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - *Kidney Neoplasms/diagnosis/genetics/pathology
MH  - *Ureteral Neoplasms/diagnosis/pathology
MH  - *Urologic Neoplasms/diagnosis
MH  - *Urinary Tract
EDAT- 2024/01/04 01:18
MHDA- 2024/04/08 06:43
CRDT- 2024/01/03 10:28
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 10:28 [entrez]
AID - 7973 [pii]
AID - 10.22037/uj.v20i.7973 [doi]
PST - epublish
SO  - Urol J. 2024 Mar 24;21(2):107-113. doi: 10.22037/uj.v20i.7973.