PMID- 38168737
OWN - NLM
STAT- MEDLINE
DCOM- 20240222
LR  - 20240301
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 64
IP  - 2
DP  - 2024 Feb
TI  - Differentiating patient characteristics between platelet refractory patients with 
      and without antibodies to human leukocyte antigens.
PG  - 210-215
LID - 10.1111/trf.17609 [doi]
AB  - BACKGROUND: Predicting whether a patient's platelet refractoriness (PR) is due to 
      immune or nonimmune causes can be challenging. This study compared the 
      demographics and clinical history of PR patients with human leukocyte antigen 
      (HLA) antibodies (HLA-PR) versus PR patients without HLA antibodies. MATERIALS 
      AND METHODS: A retrospective review of all patients with PR consults at a single 
      institution over a 3-year period was performed. Patient charts were reviewed for 
      all patients with confirmed PR, and demographic information (e.g., sex, race and 
      ethnicity, preferred language) and clinical history (e.g., pregnancy, 
      transfusion, primary diagnosis) were collected. Patient characteristics were 
      compared among the HLA and non-HLA cohorts. RESULTS: A total of 295 patients with 
      confirmed PR were identified, of whom approximately 70% did not have HLA 
      antibodies and 30% did. Approximately 84% of the HLA-PR cohort was female. A 
      history of transfusions was not associated with HLA-PR (p = .1). A history of 
      pregnancy was strongly associated with the occurrence of HLA-PR (p < .001). 
      Splenomegaly was associated with PR in the absence of HLA alloimmunization 
      whereas infection, fever, bleeding, and disseminated intravascular coagulation 
      were not. CONCLUSION: In this single-institution retrospective review, a history 
      of pregnancy was strongly associated with HLA-PR, whereas a history of 
      transfusion was not.
CI  - (c) 2024 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of 
      AABB.
FAU - Liu, Kelsey
AU  - Liu K
AD  - Department of Pathology and Laboratory Medicine, University of California San 
      Francisco, San Francisco, California, USA.
FAU - Stephens, Laura
AU  - Stephens L
AUID- ORCID: 0000-0002-9101-9326
AD  - Department of Pathology, University of California San Diego, San Diego, 
      California, USA.
FAU - Nedelcu, Elena
AU  - Nedelcu E
AUID- ORCID: 0000-0001-5981-9633
AD  - Department of Laboratory Medicine, University of California San Francisco, San 
      Francisco, California, USA.
FAU - Bakhtary, Sara
AU  - Bakhtary S
AUID- ORCID: 0000-0002-7896-2459
AD  - Department of Laboratory Medicine, University of California San Francisco, San 
      Francisco, California, USA.
LA  - eng
GR  - TR/NCATS NIH HHS/United States
GR  - NH/NIH HHS/United States
GR  - TR/NCATS NIH HHS/United States
GR  - NH/NIH HHS/United States
PT  - Journal Article
DEP - 20240103
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
RN  - 0 (Antigens, Human Platelet)
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - Platelet Transfusion/adverse effects
MH  - Blood Platelets
MH  - Blood Transfusion
MH  - HLA Antigens
MH  - *Thrombocytopenia
MH  - Isoantibodies
MH  - *Antigens, Human Platelet
OTO - NOTNLM
OT  - HLA antibodies
OT  - alloimmunization
OT  - platelet refractoriness
EDAT- 2024/01/04 01:18
MHDA- 2024/02/22 06:43
CRDT- 2024/01/03 10:57
PHST- 2023/11/07 00:00 [revised]
PHST- 2023/07/16 00:00 [received]
PHST- 2023/11/07 00:00 [accepted]
PHST- 2024/02/22 06:43 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 10:57 [entrez]
AID - 10.1111/trf.17609 [doi]
PST - ppublish
SO  - Transfusion. 2024 Feb;64(2):210-215. doi: 10.1111/trf.17609. Epub 2024 Jan 3.