PMID- 38169464
OWN - NLM
STAT- MEDLINE
DCOM- 20240109
LR  - 20240116
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 30
DP  - 2024 Jan 3
TI  - Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) 
      and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective 
      Single-Center Study.
PG  - e942079
LID - 10.12659/MSM.942079 [doi]
AB  - BACKGROUND Previous studies have identified an association between plasma levels 
      of the inflammatory cytokine, monocyte chemoattractant protein-1 (MCP-1), and 
      outcomes for patients with sepsis. This retrospective single-center study 
      assessed the association between plasma levels of MCP-1 and 28-day mortality in 
      136 patients >/=65 years diagnosed with sepsis between October 2020 and October 
      2021. MATERIAL AND METHODS The objective was to compare and analyze the 
      parameters in the survival group (n=35) and the 28-day mortality group (n=101), 
      including Sequential Organ Failure Assessment (SOFA), Acute Physiology and 
      Chronic Health Evaluation II (APACHE II), plasma MCP-1, and laboratory test 
      results. Plasma MCP-1 was quantified by cytokine test kit (LKTM014B, R&D). 
      Statistical analysis was carried out in SPSS 26.0 and MedCalc 92.1.0 software. 
      RESULTS The 28-day mortality group exhibited higher levels of SOFA, APACHEII, and 
      plasma MCP-1 (all P<0.001), as well as lower levels of albumin, compared to the 
      survival group (P<0.05). The logistic regression analysis findings indicated that 
      SOFA, APACHEII, plasma MCP-1, and SBP are all independent risk factors for 28-day 
      mortality. The area under the curve for SOFA, APACHEII, MCP-1, MCP-1+ SOFA, and 
      MCP-1+APACHEII were 0.845, 0.744, 0.712, 0.879, and 0.822, respectively. 
      MCP-1+SOFA exhibited higher sensitivity than SOFA alone. Furthermore, the 
      assessment values of plasma MCP-1 combined with SOFA were superior to those of 
      APACHE II or plasma MCP-1 (Z(1)=2.661, Z(2)=3.272, both P<0.01). CONCLUSIONS The 
      findings from this study from a single center support those of previous studies 
      that increased plasma levels of MCP-1 are significantly associated with 28-day 
      mortality in patients with sepsis.
FAU - Duan, Yunjiao
AU  - Duan Y
AUID- ORCID: 0000-0001-8699-8470
AD  - Department of Emergency, Emergency Medicine Clinical Research Center, Beijing 
      Chao-Yang Hospital, Capital Medical University, and Beijing Key Laboratory of 
      Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute 
      Infection, Capital Medical University, Beijing, China (mainland).
FAU - Liu, Min
AU  - Liu M
AD  - Department of Emergency, Emergency Medicine Clinical Research Center, Beijing 
      Chao-Yang Hospital, Capital Medical University, and Beijing Key Laboratory of 
      Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute 
      Infection, Capital Medical University, Beijing, China (mainland).
FAU - Wang, Junyu
AU  - Wang J
AD  - Department of Emergency, Emergency Medicine Clinical Research Center, Beijing 
      Chao-Yang Hospital, Capital Medical University, and Beijing Key Laboratory of 
      Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute 
      Infection, Capital Medical University, Beijing, China (mainland).
FAU - Wei, Bing
AU  - Wei B
AD  - Department of Emergency, Emergency Medicine Clinical Research Center, Beijing 
      Chao-Yang Hospital, Capital Medical University, and Beijing Key Laboratory of 
      Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute 
      Infection, Capital Medical University, Beijing, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Chemokine CCL2)
RN  - 0 (CCL2 protein, human)
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Chemokine CCL2
MH  - Intensive Care Units
MH  - Organ Dysfunction Scores
MH  - Prognosis
MH  - Retrospective Studies
MH  - ROC Curve
MH  - *Sepsis
PMC - PMC10773152
COIS- Conflict of interest: None declared
EDAT- 2024/01/04 01:18
MHDA- 2024/01/05 06:42
PMCR- 2024/01/03
CRDT- 2024/01/03 11:37
PHST- 2024/01/05 06:42 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 11:37 [entrez]
PHST- 2024/01/03 00:00 [pmc-release]
AID - 942079 [pii]
AID - 10.12659/MSM.942079 [doi]
PST - epublish
SO  - Med Sci Monit. 2024 Jan 3;30:e942079. doi: 10.12659/MSM.942079.