PMID- 38170082
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240105
IS  - 2666-9145 (Electronic)
IS  - 2666-9145 (Linking)
VI  - 4
IP  - 2
DP  - 2024 Mar-Apr
TI  - Targeted High-Density Microperimetry Testing of Nascent Geographic Atrophy in 
      Age-Related Macular Degeneration.
PG  - 100419
LID - 10.1016/j.xops.2023.100419 [doi]
LID - 100419
AB  - PURPOSE: To examine the effectiveness of a targeted high-density microperimetry 
      testing strategy for detecting visual sensitivity abnormalities in eyes with 
      nascent geographic atrophy (nGA) when compared with standard central 
      microperimetry testing. DESIGN: Observational study. PARTICIPANTS: Three-hundred 
      and twenty-one eyes from 176 individuals with nonneovascular age-related macular 
      degeneration (AMD). METHODS: Thirty-five eyes from 33 participants underwent 
      targeted high-density microperimetry testing of atrophic lesions (either nGA or 
      geographic atrophy [GA]) within a 1.75 degrees  radius (or approximately 1000 mum 
      diameter) region. Another cohort of 286 eyes from 143 participants with bilateral 
      large drusen at baseline underwent standard microperimetry testing of the central 
      6 degrees  radius region at 6-monthly intervals for up to 36 months and thus included 
      eyes that developed nGA and GA over the follow-up. All eyes underwent 2 tests at 
      each visit to evaluate intrasession measurement repeatability. MAIN OUTCOME 
      MEASURES: Magnitude of visual sensitivity abnormalities based on mean sensitivity 
      (MS), pointwise sensitivity standard deviation (PSD), and the number of test 
      locations with a threshold of </= 10 decibels (dB; or deep defects) in eyes with 
      nGA, compared between eyes that underwent targeted high-density microperimetry 
      testing and standard central microperimetry testing. RESULTS: The magnitude of 
      visual sensitivity abnormalities based on MS, PSD and the number of deep defects 
      were all significantly greater in eyes with nGA using targeted, high-density 
      microperimetry testing compared with eyes with nGA using standard central 
      microperimetry testing (all P < 0.001) and were all significantly less than eyes 
      with GA using targeted, high-density microperimetry testing (all P </= 0.004). The 
      intrasession coefficient of repeatability, where 95% of the test-retest 
      differences are expected to occur, for MS in eyes with atrophic changes was 0.9 
      dB with the targeted, high-density microperimetry testing, and 1.8 dB with 
      standard central microperimetry testing. CONCLUSIONS: Targeted, high-density 
      microperimetry testing enabled the detection of a significantly greater magnitude 
      of visual sensitivity abnormalities in eyes with nGA than standard microperimetry 
      testing. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found 
      in the Footnotes and Disclosures at the end of this article.
CI  - (c) 2023 by the American Academy of Ophthalmology.
FAU - Wu, Zhichao
AU  - Wu Z
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East 
      Melbourne, Australia.
AD  - Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, 
      Australia.
FAU - Hodgson, Lauren A B
AU  - Hodgson LAB
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East 
      Melbourne, Australia.
FAU - Guymer, Robyn H
AU  - Guymer RH
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East 
      Melbourne, Australia.
AD  - Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20231030
PL  - Netherlands
TA  - Ophthalmol Sci
JT  - Ophthalmology science
JID - 9918230896206676
PMC - PMC10758950
OTO - NOTNLM
OT  - Age-Related Macular Degeneration
OT  - Geographic Atrophy
OT  - Microperimetry
OT  - Nascent Geographic Atrophy
OT  - Visual Field Tests
EDAT- 2024/01/04 01:18
MHDA- 2024/01/04 01:19
PMCR- 2023/10/30
CRDT- 2024/01/03 12:33
PHST- 2023/06/21 00:00 [received]
PHST- 2023/10/18 00:00 [revised]
PHST- 2023/10/20 00:00 [accepted]
PHST- 2024/01/04 01:19 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 12:33 [entrez]
PHST- 2023/10/30 00:00 [pmc-release]
AID - S2666-9145(23)00151-3 [pii]
AID - 100419 [pii]
AID - 10.1016/j.xops.2023.100419 [doi]
PST - epublish
SO  - Ophthalmol Sci. 2023 Oct 30;4(2):100419. doi: 10.1016/j.xops.2023.100419. 
      eCollection 2024 Mar-Apr.