PMID- 38171038
OWN - NLM
STAT- MEDLINE
DCOM- 20240318
LR  - 20240318
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 83
DP  - 2024 May
TI  - Comparative study of nickel oxide and nickel oxide nanoparticles on oxidative 
      damage, apoptosis and histopathological alterations in rat lung tissues.
PG  - 127379
LID - S0946-672X(23)00255-9 [pii]
LID - 10.1016/j.jtemb.2023.127379 [doi]
AB  - BACKGROUND: Nickel oxide nanoparticles (NiONPs) are used as industrial 
      photoelectric and recording materials, catalysts, and sensors. It has been 
      increasingly used in many industrial sectors. Lungs are the important biological 
      barrier that comes into contact with nanomaterials in the inhaled air. This study 
      aimed to compare the effects of nickel oxide (NiO) microparticles and NiONPs on 
      rat lung tissues in different dose administrations, such as oral, 
      intraperitoneal, and intravenous. METHODS: The mature male Wistar rats (n = 42) 
      were divided into seven groups with six animals: Group I (control), Group II NiO 
      gavage (150 mg/kg), Group III NiO intraperitoneally (20 mg/kg), Group IV NiO 
      intravenously (1 mg/kg), Group V NiONP gavage (150 mg/kg), Group VI NiONP 
      intraperitoneal (20 mg/kg), and Group VII NiONP intravenous (1 mg/kg) for 21 
      days. Oxidative stress (MDA, CAT, SOD, GPx, and GST), apoptotic marker (p53) gene 
      expression, and histopathological changes were determined comparatively. RESULTS: 
      Our data showed that NiO and NiONPs caused an exposure-related increase in the 
      incidence of alveolar/bronchiolar pathological changes, oxidative damage, and p53 
      gene expression in male rats. Intravenous exposure to NiONPs produces 
      statistically (p < 0.05) more oxidative damage and histopathological changes than 
      exposure to NIO. It also induces higher upregulation of the pro-apoptotic p53 
      gene. CONCLUSION: NiO and NiONPs induce oxidative damage, histopathological 
      alterations and p53 gene expression in rat lungs. Thus, exposure to NiO and 
      NiONPs, especially intravenously, may indicate more toxicity and carcinogenicity.
CI  - Copyright (c) 2024 Elsevier GmbH. All rights reserved.
FAU - Fidan, Elif Busra
AU  - Fidan EB
AD  - Gazi University, Graduate School of Natural and Applied Sciences, Department of 
      Biology, Ankara, Turkiye.
FAU - Bali, Elif Burcu
AU  - Bali EB
AD  - Gazi University, Vocational School of Health Services, Department of Medical 
      Services and Techniques, Ankara, Turkiye. Electronic address: 
      burcubali@gazi.edu.tr.
FAU - Apaydin, Fatma Gokce
AU  - Apaydin FG
AD  - Gazi University, Faculty of Science, Department of Biology, Ankara, Turkiye.
LA  - eng
PT  - Journal Article
DEP - 20231227
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - C3574QBZ3Y (nickel monoxide)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 7OV03QG267 (Nickel)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - Rats, Wistar
MH  - *Tumor Suppressor Protein p53
MH  - Lung
MH  - Apoptosis
MH  - *Nanoparticles/toxicity
MH  - Oxidative Stress
MH  - *Nickel
OTO - NOTNLM
OT  - Apoptosis
OT  - Histopathology
OT  - Lung
OT  - Nickel oxide nanoparticles
OT  - Oxidative stress
OT  - p53
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/04 01:18
MHDA- 2024/03/18 06:42
CRDT- 2024/01/03 18:00
PHST- 2023/11/20 00:00 [received]
PHST- 2023/12/22 00:00 [revised]
PHST- 2023/12/24 00:00 [accepted]
PHST- 2024/03/18 06:42 [medline]
PHST- 2024/01/04 01:18 [pubmed]
PHST- 2024/01/03 18:00 [entrez]
AID - S0946-672X(23)00255-9 [pii]
AID - 10.1016/j.jtemb.2023.127379 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2024 May;83:127379. doi: 10.1016/j.jtemb.2023.127379. Epub 
      2023 Dec 27.