PMID- 38171651
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240105
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 327
DP  - 2024 Mar 1
TI  - Multiomics analysis revealed the mechanism of the anti-diabetic effect of 
      Salecan.
PG  - 121694
LID - S0144-8617(23)01159-1 [pii]
LID - 10.1016/j.carbpol.2023.121694 [doi]
AB  - Salecan, a natural beta-glucan compromising nine residues connected by 
      beta-(1 --> 3)/alpha-(1 --> 3) glycosidic bonds, is one of the newly approved food 
      ingredients. Salecan has multiple health-improving effects, yet its mechanism 
      against Type 2 diabetes mellitus (T2DM) remains poorly understood. In this study, 
      the hypoglycemic effect and underlying mechanism of Salecan intervention on 
      STZ-induced diabetic model mice were investigated. After 8 weeks of gavage, 
      Salecan attenuated insulin resistance and repaired pancreatic beta cells in a 
      dose-dependent manner. In addition, Salecan supplement remodel the structure of 
      the gut microbiota and altered the level of intestinal metabolites. Serum 
      metabolites, especially unsaturated fatty acids, were also affected 
      significantly. In addition, tight junction proteins in the colon and 
      autophagy-related proteins in the pancreas were upregulated. Multiomics analysis 
      indicated that Lactobacillus johnsonii, Muribaculaceae, and Lachnoclostridium 
      were highly associated with fatty acid esters of hydroxy fatty acids (FAHFA) 
      levels in the colon, accordingly enhancing arachidonic acid and linoleic acid in 
      serum, and promoting GLP-1 release in the intestine and insulin secretion in the 
      pancreas, thus relieving insulin resistance and exhibiting hypoglycemic effects. 
      These findings provide a novel understanding of the anti-diabetic effect of 
      Salecan in mice from a molecular perspective, paving the way for the wide use of 
      Salecan.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Yuan, Liyang
AU  - Yuan L
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, National Engineering Research Center for Functional Food, National 
      Engineering Laboratory for Cereal Fermentation Technology, Collaborative 
      Innovation Center of Food Safety and Quality Control in Jiangsu Province, 
      Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
FAU - Zhao, Juan
AU  - Zhao J
AD  - Sichuan Synlight Biotech Ltd, 88 Keyuan South Road, Chengdu 610000, Sichuan, 
      China.
FAU - Liu, Yanjun
AU  - Liu Y
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, National Engineering Research Center for Functional Food, National 
      Engineering Laboratory for Cereal Fermentation Technology, Collaborative 
      Innovation Center of Food Safety and Quality Control in Jiangsu Province, 
      Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
FAU - Zhao, Jialiang
AU  - Zhao J
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, National Engineering Research Center for Functional Food, National 
      Engineering Laboratory for Cereal Fermentation Technology, Collaborative 
      Innovation Center of Food Safety and Quality Control in Jiangsu Province, 
      Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
FAU - Olnood, Chen Guang
AU  - Olnood CG
AD  - Sichuan Synlight Biotech Ltd, 88 Keyuan South Road, Chengdu 610000, Sichuan, 
      China.
FAU - Xu, Yong-Jiang
AU  - Xu YJ
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, National Engineering Research Center for Functional Food, National 
      Engineering Laboratory for Cereal Fermentation Technology, Collaborative 
      Innovation Center of Food Safety and Quality Control in Jiangsu Province, 
      Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China. Electronic 
      address: yjxutju@gmail.com.
FAU - Liu, Yuanfa
AU  - Liu Y
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, National Engineering Research Center for Functional Food, National 
      Engineering Laboratory for Cereal Fermentation Technology, Collaborative 
      Innovation Center of Food Safety and Quality Control in Jiangsu Province, 
      Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China. Electronic 
      address: yfliu@jiangnan.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231213
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (salecan)
RN  - 0 (beta-Glucans)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Multiomics
MH  - *beta-Glucans/chemistry
OTO - NOTNLM
OT  - Diabetes
OT  - Gut microbiota
OT  - Metabolism
OT  - Protein
OT  - beta-Glucan
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/04 11:43
MHDA- 2024/01/05 06:42
CRDT- 2024/01/03 21:03
PHST- 2023/09/13 00:00 [received]
PHST- 2023/12/07 00:00 [revised]
PHST- 2023/12/12 00:00 [accepted]
PHST- 2024/01/05 06:42 [medline]
PHST- 2024/01/04 11:43 [pubmed]
PHST- 2024/01/03 21:03 [entrez]
AID - S0144-8617(23)01159-1 [pii]
AID - 10.1016/j.carbpol.2023.121694 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2024 Mar 1;327:121694. doi: 10.1016/j.carbpol.2023.121694. Epub 
      2023 Dec 13.