PMID- 38172147
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240108
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Jan 3
TI  - Effects of photoperiod and food on glucose intolerance and subsequent ocular 
      pathology in the fat sand rat.
PG  - 403
LID - 10.1038/s41598-023-44584-8 [doi]
LID - 403
AB  - Type 2 diabetes mellitus (T2DM) and its ocular complications, such as cataract 
      and diabetic retinopathy (DR) have been linked to circadian rhythm-disturbances. 
      Using a unique diurnal animal model, the sand rat (Psammomys obesus) we examined 
      the effect of circadian disruption by short photoperiod acclimation on the 
      development of T2DM and related ocular pathologies. We experimented with 48 male 
      sand rats. Variables were day length (short photoperiod, SP, vs. neutral 
      photoperiod NP) and diet (standard rodent diet vs. low-energy diet). Blood 
      glucose, the presence of cataract and retinal pathology were monitored. 
      Histological slides were examined for lens opacity, retinal cell count and 
      thickness. Animals under SP and fed standard rodent diet (SPSR) for 20 weeks had 
      higher baseline blood glucose levels and lower glucose tolerance compared with 
      animals kept under NP regardless of diet, and under SP with low energy diet 
      (SPLE). Animals under SPSR had less cells in the outer nuclear layer, a lower 
      total number of cells in the retina, and a thickened retina. Higher blood glucose 
      levels correlated with lower number of cells in all cellular layers of the retina 
      and thicker retina. Animals under SPSR had higher occurrence of cataract, and a 
      higher degree of cataract, which correlated with higher blood glucose levels. 
      Sand rats kept under SPSR develop cataract and retinal abnormalities indicative 
      of DR, whereas sand rats kept under NP regardless of diet, or under SPLE, do not. 
      These ocular abnormalities significantly correlate with hyperglycemia.
CI  - (c) 2023. The Author(s).
FAU - Bilu, Carmel
AU  - Bilu C
AD  - School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel. 
      Carmel.bilu@gmail.com.
FAU - Butensky, Neta
AU  - Butensky N
AD  - School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel.
FAU - Malamud, Amit Richter
AU  - Malamud AR
AD  - School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel.
FAU - Einat, Haim
AU  - Einat H
AD  - School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel.
FAU - Zimmet, Paul
AU  - Zimmet P
AD  - Department of Medicine, Monash University, Melbourne, VIC, Australia.
FAU - Zloto, Ofira
AU  - Zloto O
AD  - Ocular Oncology, The Goldschleger Eye Institute, The Chaim Sheba Medical Center, 
      Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
FAU - Ziv, Hana
AU  - Ziv H
AD  - Maurice and Gabriela Goldschleger Eye Research Institute, The Chaim Sheba Medical 
      Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, 
      Israel.
FAU - Kronfeld-Schor, Noga
AU  - Kronfeld-Schor N
AD  - School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel.
FAU - Vishnevskia-Dai, Vicktoria
AU  - Vishnevskia-Dai V
AD  - Ocular Oncology, The Goldschleger Eye Institute, The Chaim Sheba Medical Center, 
      Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Male
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Photoperiod
MH  - Gerbillinae
MH  - Blood Glucose
MH  - *Glucose Intolerance/complications
MH  - *Diabetic Retinopathy/complications
MH  - *Hyperglycemia/complications
MH  - *Cataract/pathology
PMC - PMC10764329
COIS- The authors declare no competing interests.
EDAT- 2024/01/04 11:43
MHDA- 2024/01/05 06:43
PMCR- 2024/01/03
CRDT- 2024/01/03 23:16
PHST- 2022/12/24 00:00 [received]
PHST- 2023/10/10 00:00 [accepted]
PHST- 2024/01/05 06:43 [medline]
PHST- 2024/01/04 11:43 [pubmed]
PHST- 2024/01/03 23:16 [entrez]
PHST- 2024/01/03 00:00 [pmc-release]
AID - 10.1038/s41598-023-44584-8 [pii]
AID - 44584 [pii]
AID - 10.1038/s41598-023-44584-8 [doi]
PST - epublish
SO  - Sci Rep. 2024 Jan 3;14(1):403. doi: 10.1038/s41598-023-44584-8.