PMID- 38172442
OWN - NLM
STAT- Publisher
LR  - 20240103
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
DP  - 2024 Jan 4
TI  - High-resolution MRI vessel wall enhancement in moyamoya disease: risk factors and 
      clinical outcomes.
LID - 10.1007/s00330-023-10535-0 [doi]
AB  - OBJECTIVES: Intracranial vessel wall enhancement (VWE) on high-resolution 
      magnetic resonance imaging (HRMRI) is associated with the progression and poor 
      prognosis of moyamoya disease (MMD). This study assessed potential risk factors 
      for VWE in MMD. METHODS: We evaluated MMD patients using HRMRI and traditional 
      angiography examinations. The participants were divided into VWE and non-VWE 
      groups based on HRMRI. Logistic regression was performed to compare the risk 
      factors for VWE in MMD. The incidence of cerebrovascular events of the different 
      subgroups according to risk factors was compared using Kaplan-Meier survival and 
      Cox regression. RESULTS: We included 283 MMD patients, 84 of whom had VWE on 
      HRMRI. The VWE group had higher modified Rankin Scale scores at admission 
      (p = 0.014) and a higher incidence of ischaemia and haemorrhage (p = 0.002) than 
      did the non-VWE group. Risk factors for VWE included the ring finger protein 213 
      (RNF213) p.R4810K variant (odds ratio [OR] 2.01, 95% confidence interval [CI] 
      1.08-3.76, p = 0.028), hyperhomocysteinaemia (HHcy) (OR 5.08, 95% CI 2.34-11.05, 
      p < 0.001), and smoking history (OR 3.49, 95% CI 1.08-11.31, p = 0.037). During 
      the follow-up of 63.9 +/- 13.2 months (median 65 months), 18 recurrent stroke 
      events occurred. Cox regression showed that VWE and the RNF213 p.R4810K variant 
      were risk factors for stroke. CONCLUSION: The RNF213 p.R4810K variant is strongly 
      associated with VWE and poor prognosis in MMD. HHcy and smoking are independent 
      risk factors for VWE. CLINICAL RELEVANCE STATEMENT: Vessel wall enhancement in 
      moyamoya disease is closely associated with poor prognosis, especially related to 
      the ring finger protein 213 p.R4810K variant, hyperhomocysteinaemia, and smoking, 
      providing crucial risk assessment information for the clinic. KEY POINTS: * The 
      baseline presence of vessel wall enhancement is significantly associated with 
      poor prognosis in moyamoya disease. * The ring finger protein 213 p.R4810K 
      variant is strongly associated with vessel wall enhancement and poor prognosis in 
      moyamoya disease. * Hyperhomocysteinaemia and smoking are independent risk 
      factors for vessel wall enhancement in moyamoya disease.
CI  - (c) 2024. The Author(s), under exclusive licence to European Society of Radiology.
FAU - Hao, Fangbin
AU  - Hao F
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Han, Cong
AU  - Han C
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Lu, Mingming
AU  - Lu M
AD  - Department of Radiology, the Fifth Medical Centre, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Gao, Gan
AU  - Gao G
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Wang, Qiannan
AU  - Wang Q
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Liu, Shitong
AU  - Liu S
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Radiology, the Fifth Medical Centre, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Liu, Simeng
AU  - Liu S
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Wang, Minjie
AU  - Wang M
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Ren, Bin
AU  - Ren B
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Zou, Zhengxing
AU  - Zou Z
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Yu, Dan
AU  - Yu D
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Sun, Caihong
AU  - Sun C
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Guo, Qingbao
AU  - Guo Q
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Liu, Wanyang
AU  - Liu W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Sun, Zhenghui
AU  - Sun Z
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Cai, Jianming
AU  - Cai J
AD  - Department of Radiology, the Fifth Medical Centre, Chinese PLA General Hospital, 
      Beijing, China. beili12345@sina.cn.
FAU - Duan, Lian
AU  - Duan L
AUID- ORCID: 0000-0001-7210-056X
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China. 
      duanlian307@sina.com.
AD  - Department of Neurosurgery, the Fifth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China. duanlian307@sina.com.
LA  - eng
GR  - 82171280/National Natural Science Foundation of China/
GR  - 82172021/National Natural Science Foundation of China/
GR  - 2019-JCJQ-ZD-195-00/Science and Technology Commission Project/
PT  - Journal Article
DEP - 20240104
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
OTO - NOTNLM
OT  - High-resolution magnetic resonance imaging
OT  - Hyperhomocysteinaemia
OT  - Moyamoya disease
OT  - Ring finger protein 213
OT  - Vessel wall enhancement
EDAT- 2024/01/04 11:43
MHDA- 2024/01/04 11:43
CRDT- 2024/01/03 23:32
PHST- 2023/08/17 00:00 [received]
PHST- 2023/11/25 00:00 [accepted]
PHST- 2023/10/20 00:00 [revised]
PHST- 2024/01/04 11:43 [medline]
PHST- 2024/01/04 11:43 [pubmed]
PHST- 2024/01/03 23:32 [entrez]
AID - 10.1007/s00330-023-10535-0 [pii]
AID - 10.1007/s00330-023-10535-0 [doi]
PST - aheadofprint
SO  - Eur Radiol. 2024 Jan 4. doi: 10.1007/s00330-023-10535-0.