PMID- 38172797
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240106
IS  - 2662-7671 (Electronic)
IS  - 2662-7671 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Jan 3
TI  - Supplementation of papaya leaf juice has beneficial effects on glucose 
      homeostasis in high fat/high sugar-induced obese and prediabetic adult mice.
PG  - 18
LID - 10.1186/s12906-023-04320-1 [doi]
LID - 18
AB  - Prediabetes is characterized by a cluster of glycemic parameters higher than 
      normal but below the threshold of type 2 diabetes mellitus (T2DM). In recent 
      years, phytochemical-rich plant extracts have gained popularity as therapeutic 
      agents for metabolic disorders. This study investigated the effects of papaya 
      leaf (PL) juice supplementation on blood glucose levels in diet-induced obese and 
      prediabetic adult mice. B65JL F1 mice (n = 20) at 12-14 months old were fed a 
      high fat/sugar diet (HFHS) for 120 days. Mice were switched to restricted rodent 
      chow of 3 g feed/30 g body weight/day, supplemented with 3 g/100 mL PL juice for 
      30 days. HFHS diet remarkably increased fasting plasma glucose levels from 
      114 +/- 6.54 mg/dL to 192.7 +/- 10.1 mg/dL and body weight from 32.5 +/- 1.6 to 
      50.3 +/- 4.1 g. HFHS diet results in hyperglycemia, insulin resistance, 
      hyperlipidemia, and liver steatosis. The combination of PL juice and restricted 
      diet significantly reduced body weight and fasting blood glucose levels to 
      43.75 +/- 1.4 g and 126.25 +/- 3.2 mg/dl, respectively. Moreover, PL juice with a 
      restricted diet significantly improved lipid profile: cholesterol from 204 to 
      150 mg/dL, LDL-c from 110.4 to 50 mg/dL, and triglyceride from 93.7 to 60 mg/dL. 
      Additionally, PL juice combined with a restricted diet significantly reduced 
      adiposity, reversed fatty liver, and restored skeletal muscle Glut4 and 
      phosphorylated (p-AKT (ser473). This study demonstrated that supplementation of 
      PL juice with a restricted diet was more effective than a restricted diet alone 
      in reversing major symptoms related to prediabetic and obesity conditions.
CI  - (c) 2023. The Author(s).
FAU - Nyakundi, Benard B
AU  - Nyakundi BB
AD  - Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at 
      Manoa, Honolulu, Hawaii, 96822, USA.
FAU - Wall, Marisa M
AU  - Wall MM
AD  - Daniel K. Inouye U.S. Pacific Basin Agricultural Research Center, USDA-ARS, Hilo, 
      HI, 96720, USA.
FAU - Yang, Jinzeng
AU  - Yang J
AD  - Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at 
      Manoa, Honolulu, Hawaii, 96822, USA. jinzeng@hawaii.edu.
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - England
TA  - BMC Complement Med Ther
JT  - BMC complementary medicine and therapies
JID - 101761232
RN  - 0 (Sugars)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Sugars/therapeutic use
MH  - *Carica/metabolism
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - *Prediabetic State/drug therapy
MH  - Obesity/drug therapy/metabolism
MH  - *Fatty Liver/drug therapy
MH  - Body Weight
MH  - Diet, High-Fat/adverse effects
MH  - Dietary Supplements
MH  - Homeostasis
MH  - Plant Leaves
PMC - PMC10765817
OTO - NOTNLM
OT  - Blood glucose
OT  - Diabetes
OT  - Insulin sensitivity
OT  - Papaya leaf
OT  - Prediabetes
COIS- The authors declare no competing interests.
EDAT- 2024/01/04 11:45
MHDA- 2024/01/05 06:43
PMCR- 2024/01/03
CRDT- 2024/01/03 23:50
PHST- 2023/10/04 00:00 [received]
PHST- 2023/12/18 00:00 [accepted]
PHST- 2024/01/05 06:43 [medline]
PHST- 2024/01/04 11:45 [pubmed]
PHST- 2024/01/03 23:50 [entrez]
PHST- 2024/01/03 00:00 [pmc-release]
AID - 10.1186/s12906-023-04320-1 [pii]
AID - 4320 [pii]
AID - 10.1186/s12906-023-04320-1 [doi]
PST - epublish
SO  - BMC Complement Med Ther. 2024 Jan 3;24(1):18. doi: 10.1186/s12906-023-04320-1.