PMID- 38173120
OWN - NLM
STAT- Publisher
LR  - 20240104
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
DP  - 2024 Jan 3
TI  - Liraglutide does not increase heart rate of diabetic patients during acute 
      myocardial infarction.
LID - 10.1111/1753-0407.13517 [doi]
AB  - BACKGROUND: Glucagon-like peptide 1 receptor agonists have been shown to reduce 
      all-cause and cardiovascular mortality in patients with Type 2 diabetes mellitus 
      (T2DM). The probable increase in heart rate hinders its early usage in acute 
      myocardial infarction patients. In our study, we aimed to find out whether the 
      use of liraglutide in patients with acute myocardial infarction as early as at 
      the time of hospitalization would increase the heart rate. METHODS: This was an 
      observational retrospective study. From December 2020 to August 2021, 200 
      patients with acute myocardial infarction were included in our study and divided 
      into three groups: T2DM + liraglutide group (n = 46), T2DM + non-liraglutide 
      group (n = 42), and non-T2DM group (n = 112). The primary outcomes were the 
      differences in heart rate. Secondary outcomes were differences in systolic and 
      diastolic blood pressure. RESULTS: There were no significant differences in heart 
      rate among the three groups at admission, the day before the first shot of 
      liraglutide, and before discharge. There was also no significant difference in 
      heart rate between diabetic patients with acute myocardial infarction and those 
      on liraglutide during the hospital stay. And there were no differences of 
      beta-blocker dosages among the three groups. Liraglutide did not affect the blood 
      pressure during acute myocardial infarction. CONCLUSIONS: Liraglutide did not 
      increase the heart rate in diabetic patients during acute myocardial infarction 
      and did not lead to an increase in the dose of beta-blockers in the patients. It 
      also had no effect on blood pressure and showed better efficacy in lowering 
      glucose levels without additional hypoglycemic events.
CI  - (c) 2024 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Li, Qianyi
AU  - Li Q
AUID- ORCID: 0000-0003-4636-1349
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Wu, Chunxuan
AU  - Wu C
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Sun, Shiqun
AU  - Sun S
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Yang, Lingchao
AU  - Yang L
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Li, Yanyan
AU  - Li Y
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Niu, Yixin
AU  - Niu Y
AD  - Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Yu, Ying
AU  - Yu Y
AD  - Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
LA  - eng
GR  - 81770321/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20240103
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
OTO - NOTNLM
OT  - GLP-1RA
OT  - Type 2 diabetes mellitus
OT  - acute myocardial infarction
OT  - blood pressure
OT  - heart rate
EDAT- 2024/01/04 11:44
MHDA- 2024/01/04 11:44
CRDT- 2024/01/04 00:23
PHST- 2023/11/06 00:00 [revised]
PHST- 2023/02/12 00:00 [received]
PHST- 2023/11/18 00:00 [accepted]
PHST- 2024/01/04 11:44 [medline]
PHST- 2024/01/04 11:44 [pubmed]
PHST- 2024/01/04 00:23 [entrez]
AID - 10.1111/1753-0407.13517 [doi]
PST - aheadofprint
SO  - J Diabetes. 2024 Jan 3. doi: 10.1111/1753-0407.13517.