PMID- 38173370 OWN - NLM STAT- MEDLINE DCOM- 20240207 LR - 20240210 IS - 2233-6087 (Electronic) IS - 2233-6079 (Print) IS - 2233-6079 (Linking) VI - 48 IP - 1 DP - 2024 Jan TI - Psychotic Disorders and the Risk of Type 2 Diabetes Mellitus, Atherosclerotic Cardiovascular Diseases, and All-Cause Mortality: A Population-Based Matched Cohort Study. PG - 122-133 LID - 10.4093/dmj.2022.0431 [doi] AB - BACKGRUOUND: The effects of psychotic disorders on cardiometabolic diseases and premature death need to be determined in Asian populations. METHODS: In this population-based matched cohort study, the Korean National Health Insurance Service database (2002 to 2018) was used. The risk of type 2 diabetes mellitus (T2DM), acute myocardial infarction (AMI), ischemic stroke, composite of all cardiometabolic diseases, and all-cause death during follow-up was compared between individuals with psychotic disorders treated with antipsychotics (n=48,162) and 1:1 matched controls without psychiatric disorders among adults without cardiometabolic diseases before or within 3 months after baseline. RESULTS: In this cohort, 53,683 composite cases of all cardiometabolic diseases (during median 7.38 years), 899 AMI, and 1,216 ischemic stroke cases (during median 14.14 years), 7,686 T2DM cases (during median 13.26 years), and 7,092 deaths (during median 14.23 years) occurred. The risk of all outcomes was higher in subjects with psychotic disorders than matched controls (adjusted hazard ratios [95% confidence intervals]: 1.522 [1.446 to 1.602] for T2DM; 1.455 [1.251 to 1.693] for AMI; 1.568 [1.373 to 1.790] for ischemic stroke; 1.595 [1.565 to 1.626] for composite of all cardiometabolic diseases; and 2.747 [2.599 to 2.904] for all-cause mortality) during follow-up. Similar patterns of associations were maintained in subgroup analyses but more prominent in younger individuals (P for interaction <0.0001) when categorized as those aged 18-39, 40-64, or >/=65 years. CONCLUSION: Patients with psychotic disorders treated with antipsychotics were associated with increased risk of premature allcause mortality and cardiometabolic outcomes in an Asian population. This relationship was more pronounced in younger individuals, especially aged 18 to 39 years. FAU - Lee, You-Bin AU - Lee YB AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Kim, Hyewon AU - Kim H AD - Department of Psychiatry, Hanyang University Hospital, Seoul, Korea. FAU - Lee, Jungkuk AU - Lee J AD - Data Science Team, Hanmi Pharm. Co., Ltd., Seoul, Korea. FAU - Kang, Dongwoo AU - Kang D AD - Data Science Team, Hanmi Pharm. Co., Ltd., Seoul, Korea. FAU - Kim, Gyuri AU - Kim G AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Jin, Sang-Man AU - Jin SM AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Kim, Jae Hyeon AU - Kim JH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Jeon, Hong Jin AU - Jeon HJ AD - Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Hur, Kyu Yeon AU - Hur KY AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. LA - eng GR - Korea Health Industry Development Institute/ GR - HR21C0885/Ministry of Health and Welfare/ GR - SMX1230041/Samsung Medical Center/ PT - Journal Article DEP - 20240103 PL - Korea (South) TA - Diabetes Metab J JT - Diabetes & metabolism journal JID - 101556588 SB - IM MH - Adult MH - Humans MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - *Cardiovascular Diseases/etiology MH - Cohort Studies MH - *Myocardial Infarction/epidemiology MH - *Atherosclerosis MH - *Ischemic Stroke/complications MH - *Psychotic Disorders/complications/epidemiology PMC - PMC10850276 OTO - NOTNLM OT - Diabetes mellitus, type 2 OT - Ischemic stroke OT - Mortality OT - Myocardial infarction OT - Psychotic disorders COIS- CONFLICTS OF INTEREST Sang-Man Jin has been associate editor of the Diabetes & Metabolism Journal since 2022. He was not involved in the review process of this article. Otherwise, there was no conflict of interest. Two of the authors in this study are affiliated with the Data Science Team at Hanmi Pharm. Co., Ltd., Seoul, Korea, which is a for-profit organization. We hereby declare that there are no potential conflicts of interest arising from this affiliation in relation to the research, methodology, results, and conclusions presented in this article. The authors from Hanmi Pharm. Co., Ltd. have participated in this study solely in the capacity of independent researchers, and their involvement has not been influenced by any financial or proprietary interests of the company. EDAT- 2024/01/04 11:44 MHDA- 2024/02/07 06:42 PMCR- 2024/01/01 CRDT- 2024/01/04 03:16 PHST- 2022/12/05 00:00 [received] PHST- 2023/02/27 00:00 [accepted] PHST- 2024/02/07 06:42 [medline] PHST- 2024/01/04 11:44 [pubmed] PHST- 2024/01/04 03:16 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - dmj.2022.0431 [pii] AID - dmj-2022-0431 [pii] AID - 10.4093/dmj.2022.0431 [doi] PST - ppublish SO - Diabetes Metab J. 2024 Jan;48(1):122-133. doi: 10.4093/dmj.2022.0431. Epub 2024 Jan 3.