PMID- 38173603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240105
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Jan 2
TI  - Perfluoropolyether-incorporated polyurethane with enhanced antibacterial and 
      anti-adhesive activities for combating catheter-induced infection.
PG  - 568-576
LID - 10.1039/d3ra07831k [doi]
AB  - To avoid the undesired bacterial attachment on polyurethane-based biomedical 
      devices, we designed a class of novel perfluoropolyether-incorporated 
      polyurethanes (PFPU) containing different contents of perfluoropolyether (PFPE) 
      segments. After blending with Ag nanoparticles (AgNPs), a series of bifunctional 
      PFPU/AgNPs composites with bactericidal and anti-adhesion abilities were obtained 
      and correspondingly made into PFPU/AgNPs films (PFPU/Ag-F) using a simple 
      solvent-casting method. Due to its highest hydrophobicity and suitable mechanical 
      properties, PFPU8/Ag-F containing 8 mol% of PFPE content was chosen as the 
      optimized one for the next antibacterial assessment. The PFPU8/Ag-F can 
      effectively deactivate over 99.9% of Staphylococcus aureus (S. aureus) and 
      Escherichia coli (E. coli) cells at 10(6) CFU mL(-1) within 30 min. Furthermore, 
      the PFPU8/AgNPs composite was used as painting material to form a protective 
      coating for the commercial polyurethane (PU) catheter. The as-prepared PFPU8/Ag 
      coating exhibits high resistance to bacterial adhesion in a continuous-flow 
      artificial urine model in an 8 day exposure. Therefore, it can be expected that 
      the proposed PFPE-containing films and coatings can effectively prevent bacterial 
      colonization and biofilm formation on catheters or other implants, thereby 
      reducing the risk of postoperative catheter-induced infection.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Song, Guangbin
AU  - Song G
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Hu, Can
AU  - Hu C
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Liu, Zixu
AU  - Liu Z
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Liu, Huansen
AU  - Liu H
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Wang, Yilei
AU  - Wang Y
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Wang, Liang
AU  - Wang L
AUID- ORCID: 0000-0001-6542-761X
AD  - School of Chemistry and Chemical Engineering, Tianjin University of Technology 
      Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.
FAU - Feng, Xuequan
AU  - Feng X
AD  - Neurosurgery Department, Tianjin First Centre Hospital Tianjin China 
      fengxuequan@126.com.
LA  - eng
PT  - Journal Article
DEP - 20240102
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC10759042
COIS- There are no conflicts to declare.
EDAT- 2024/01/04 11:44
MHDA- 2024/01/04 11:45
PMCR- 2024/01/02
CRDT- 2024/01/04 03:57
PHST- 2023/11/16 00:00 [received]
PHST- 2023/12/13 00:00 [accepted]
PHST- 2024/01/04 11:45 [medline]
PHST- 2024/01/04 11:44 [pubmed]
PHST- 2024/01/04 03:57 [entrez]
PHST- 2024/01/02 00:00 [pmc-release]
AID - d3ra07831k [pii]
AID - 10.1039/d3ra07831k [doi]
PST - epublish
SO  - RSC Adv. 2024 Jan 2;14(1):568-576. doi: 10.1039/d3ra07831k. eCollection 2024 Jan 
      2.