PMID- 38173712
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240105
IS  - 2221-285X (Electronic)
IS  - 1818-0876 (Print)
IS  - 1818-0876 (Linking)
VI  - 18
IP  - 6
DP  - 2023 Nov
TI  - Smart stimuli-responsive drug delivery systems in spotlight of COVID-19.
PG  - 100873
LID - 10.1016/j.ajps.2023.100873 [doi]
LID - 100873
AB  - The world has been dealing with a novel severe acute respiratory syndrome 
      (SARS-CoV-2) since the end of 2019, which threatens the lives of many people 
      worldwide. COVID-19 causes respiratory infection with different symptoms, from 
      sneezing and coughing to pneumonia and sometimes gastric symptoms. Researchers 
      worldwide are actively developing novel drug delivery systems (DDSs), such as 
      stimuli-responsive DDSs. The ability of these carriers to respond to 
      external/internal and even multiple stimuli is essential in creating "smart" DDS 
      that can effectively control dosage, sustained release, individual variations, 
      and targeted delivery. To conduct a comprehensive literature survey for this 
      article, the terms "Stimuli-responsive", "COVID-19'' and "Drug delivery" were 
      searched on databases/search engines like "Google Scholar", "NCBI", "PubMed", and 
      "Science Direct". Many different types of DDSs have been proposed, including 
      those responsive to various exogenous (light, heat, ultrasound and magnetic 
      field) or endogenous (microenvironmental changes in pH, ROS and enzymes) stimuli. 
      Despite significant progress in DDS research, several challenging issues must be 
      addressed to fill the gaps in the literature. Therefore, this study reviews the 
      drug release mechanisms and applications of endogenous/exogenous 
      stimuli-responsive DDSs while also exploring their potential with respect to 
      COVID-19.
CI  - (c) 2023 Shenyang Pharmaceutical University. Published by Elsevier B.V.
FAU - Najjari, Zeinab
AU  - Najjari Z
AD  - Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, School 
      of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Sadri, Farzaneh
AU  - Sadri F
AD  - Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, School 
      of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Varshosaz, Jaleh
AU  - Varshosaz J
AD  - Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, School 
      of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231201
PL  - Netherlands
TA  - Asian J Pharm Sci
JT  - Asian journal of pharmaceutical sciences
JID - 101535338
PMC - PMC10762358
OTO - NOTNLM
OT  - Biomedical applications
OT  - COVID-19
OT  - Endogenous and exogenous stimuli
OT  - Smart drug delivery system
OT  - Stimuli-responsive
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/04 11:43
MHDA- 2024/01/04 11:44
PMCR- 2023/12/01
CRDT- 2024/01/04 04:03
PHST- 2023/05/18 00:00 [received]
PHST- 2023/08/15 00:00 [revised]
PHST- 2023/10/11 00:00 [accepted]
PHST- 2024/01/04 11:44 [medline]
PHST- 2024/01/04 11:43 [pubmed]
PHST- 2024/01/04 04:03 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - S1818-0876(23)00098-3 [pii]
AID - 100873 [pii]
AID - 10.1016/j.ajps.2023.100873 [doi]
PST - ppublish
SO  - Asian J Pharm Sci. 2023 Nov;18(6):100873. doi: 10.1016/j.ajps.2023.100873. Epub 
      2023 Dec 1.