PMID- 38173786
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240105
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 49
DP  - 2023 Dec
TI  - A cross-sectional study in type 2 diabetes patients reveals that elevated pulse 
      wave velocity predicts asymptomatic peripheral arterial disease associated with 
      age and diabetes duration.
PG  - 101308
LID - 10.1016/j.ijcha.2023.101308 [doi]
LID - 101308
AB  - BACKGROUND: Peripheral arterial disease (PAD) reduces functional capacity and 
      raises cardiovascular risks, but underdiagnosis is common, resulting in less 
      comprehensive care than other cardiovascular conditions. While diabetes has long 
      been viewed as a key risk factor for PAD, recent studies indicate that its impact 
      is influenced by the presence of concurrent cardiovascular risk factors. The aim 
      of this study is to elucidate the intricate relationship between the prevalence 
      of PAD, diabetic complications, and cardiovascular risk factors among 
      asymptomatic patients with type 2 diabetes mellitus (T2DM). METHODS: Ninety-one 
      patients with T2DM and no symptoms or previous diagnosis of PAD were recruited 
      from the outpatient diabetic clinic. Clinical data were extracted from electronic 
      medical records, and the screening for PAD was conducted using MESI mTABLET. 
      RESULTS: Screening for PAD among asymptomatic individuals with T2DM revealed that 
      5.49 % of patients exhibit a low ankle-brachial index (ABI). Patients who had 
      previously experienced major adverse cardiovascular events or exhibited 
      albuminuria displayed lower ABI values. Furthermore, a striking 45.05 % of the 
      participants displayed an abnormally high carotid-femoral pulse wave velocity 
      (cfPWV) value, with elevated PWV values correlating with advanced age and longer 
      diabetes duration. CONCLUSIONS: The prevalence of elevated cfPWV is more 
      pronounced than that of decreased ABI in T2DM patients with asymptomatic PAD and 
      is associated with older age and longer diabetes duration, therefore measurement 
      of both ABI and PWV is crucial for the cardiovascular risk assessment protocol 
      for patients with T2DM and timely PAD diagnosis.
CI  - (c) 2023 The Authors.
FAU - Gasparini, Dora
AU  - Gasparini D
AD  - Center for Diabetes, Endocrinology and Cardiometabolism, Special Hospital for 
      Medical Rehabilitation of Cardiac, Pulmonary and Rheumatic diseases 
      Thalassotherapia Opatija, Marsala Tita 188/1, 51410 Opatija, Croatia.
AD  - Department of Histology and Embryology, Faculty of Medicine, University of 
      Rijeka, Brace Branchetta 20/1, 51000 Rijeka, Croatia.
FAU - Zuljani, Anamaria
AU  - Zuljani A
AD  - Department of Emergency Medicine, Clinical Hospital Center Rijeka, Tome Strizica 
      3, 51000 Rijeka, Croatia.
FAU - Wensveen, Felix M
AU  - Wensveen FM
AD  - Department of Histology and Embryology, Faculty of Medicine, University of 
      Rijeka, Brace Branchetta 20/1, 51000 Rijeka, Croatia.
FAU - Turk Wensveen, Tamara
AU  - Turk Wensveen T
AD  - Center for Diabetes, Endocrinology and Cardiometabolism, Special Hospital for 
      Medical Rehabilitation of Cardiac, Pulmonary and Rheumatic diseases 
      Thalassotherapia Opatija, Marsala Tita 188/1, 51410 Opatija, Croatia.
AD  - Department of Internal Medicine, Faculty of Medicine, University of Rijeka, Brace 
      Branchetta 20/1, 51000 Rijeka, Croatia.
AD  - Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital 
      Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20231126
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC10761307
OTO - NOTNLM
OT  - Ankle Brachial Index
OT  - Diabetes Mellitus, Type 2
OT  - Peripheral Arterial Disease
OT  - Pulse Wave Analysis
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/01/04 11:43
MHDA- 2024/01/04 11:44
PMCR- 2023/11/26
CRDT- 2024/01/04 04:06
PHST- 2023/08/31 00:00 [received]
PHST- 2023/11/08 00:00 [revised]
PHST- 2023/11/15 00:00 [accepted]
PHST- 2024/01/04 11:44 [medline]
PHST- 2024/01/04 11:43 [pubmed]
PHST- 2024/01/04 04:06 [entrez]
PHST- 2023/11/26 00:00 [pmc-release]
AID - S2352-9067(23)00139-2 [pii]
AID - 101308 [pii]
AID - 10.1016/j.ijcha.2023.101308 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2023 Nov 26;49:101308. doi: 
      10.1016/j.ijcha.2023.101308. eCollection 2023 Dec.