PMID- 38173970
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240105
IS  - 2471-1888 (Electronic)
IS  - 2471-1888 (Linking)
VI  - 9
IP  - 4
DP  - 2023
TI  - Cholesterol dependent cytolysins and the brain: Revealing a potential therapeutic 
      avenue for bacterial meningitis.
PG  - 647-667
LID - 10.3934/microbiol.2023033 [doi]
AB  - Bacterial meningitis is a catastrophic nervous system disorder with high 
      mortality and wide range of morbidities. Some of the meningitis-causing bacteria 
      occupy cholesterol dependent cytolysins (CDCs) to increase their pathogenicity 
      and arrange immune-evasion strategy. Studies have observed that the relationship 
      between CDCs and pathogenicity in these meningitides is complex and involves 
      interactions between CDC, blood-brain barrier (BBB), glial cells and neurons. In 
      BBB, these CDCs acts on capillary endothelium, tight junction (TJ) proteins and 
      neurovascular unit (NVU). CDCs also observed to elicit intriguing effects on 
      brain inflammation which involves microglia and astrocyte activations, along with 
      neuronal damage as the end-point of pathological pathways in bacterial 
      meningitis. As some studies mentioned potential advantage of CDC-targeted 
      therapeutic mechanisms to combat CNS infections, it might be a fruitful avenue to 
      deepen our understanding of CDC as a candidate for adjuvant therapy to combat 
      bacterial meningitis.
CI  - (c) 2023 the Author(s), licensee AIMS Press.
FAU - Pramitasuri, Tjokorda Istri
AU  - Pramitasuri TI
AD  - Doctoral Program in Medical Science, Faculty of Medicine, Universitas Udayana, 
      Bali, Indonesia.
AD  - Postgraduate Research Student, Faculty of Medicine, Imperial College London, 
      United Kingdom.
FAU - Susilawathi, Ni Made
AU  - Susilawathi NM
AD  - Department of Neurology, Faculty of Medicine, Universitas Udayana, Bali, 
      Indonesia.
FAU - Tarini, Ni Made Adi
AU  - Tarini NMA
AD  - Department of Microbiology, Faculty of Medicine, Universitas Udayana-Rumah Sakit 
      Umum Pusat Prof Dr dr IGNG Ngoerah, Bali, Indonesia.
FAU - Sudewi, Aa Raka
AU  - Sudewi AR
AD  - Department of Neurology, Faculty of Medicine, Universitas Udayana, Bali, 
      Indonesia.
FAU - Evans, Matthew C
AU  - Evans MC
AD  - Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial 
      College London, United Kingdom.
AD  - Department of Brain Sciences, Care Research and Technology Centre, UK Dementia 
      Research Institute, London, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230821
PL  - United States
TA  - AIMS Microbiol
JT  - AIMS microbiology
JID - 101697141
PMC - PMC10758573
OTO - NOTNLM
OT  - bacteria
OT  - brain
OT  - central nervous system
OT  - cholesterol dependent cytolysin
OT  - meningitis
COIS- Conflict of interest: The authors declare that there were no financial or 
      commercial ties that might be viewed as potential conflicts of interest during 
      the conduct of this manuscript.
EDAT- 2024/01/04 11:43
MHDA- 2024/01/04 11:44
PMCR- 2023/08/21
CRDT- 2024/01/04 04:13
PHST- 2023/05/18 00:00 [received]
PHST- 2023/07/24 00:00 [revised]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2024/01/04 11:44 [medline]
PHST- 2024/01/04 11:43 [pubmed]
PHST- 2024/01/04 04:13 [entrez]
PHST- 2023/08/21 00:00 [pmc-release]
AID - microbiol-09-04-033 [pii]
AID - 10.3934/microbiol.2023033 [doi]
PST - epublish
SO  - AIMS Microbiol. 2023 Aug 21;9(4):647-667. doi: 10.3934/microbiol.2023033. 
      eCollection 2023.