PMID- 38174616
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240216
IS  - 1549-8719 (Electronic)
IS  - 1073-9688 (Linking)
VI  - 31
IP  - 2
DP  - 2024 Feb
TI  - Coronary microvascular dysfunction as assessed by multimodal diagnostic imaging 
      in patients with hypertrophic cardiomyopathy is related to the severity of 
      cardiac dysfunction.
PG  - e12843
LID - 10.1111/micc.12843 [doi]
AB  - INTRODUCTION: Coronary microvascular dysfunction (CMD) plays a major role in 
      hypertrophic cardiomyopathy (HCM) physiopathology but its assessment in clinical 
      practice remains a challenge. Nowadays, innovations in invasive and noninvasive 
      coronary evaluation using multimodal imaging provide options for the diagnosis of 
      CMD. The objective of the present study was to investigate if new multimodal 
      imaging diagnosis of CMD could detect HCM patients with more impaired cardiac 
      function by left atrioventricular coupling index (LACI). METHODS AND RESULTS: A 
      total of 32 consecutive patients with a confirmed diagnosis of HCM 
      (62 +/- 13 years, 62% men) were prospectively screened for CMD using a multimodal 
      imaging method. LACI was assessed by cardiovascular magnetic resonance imaging. 
      Fifteen (47%) patients had CMD by multimodal imaging method. Patients with CMD 
      presented a significantly higher LACI (48.5 +/- 25.4 vs. 32.5 +/- 10.6, p = .03). A 
      multivariate logistic regression analysis demonstrated that CMD was independently 
      associated with LACI (OR = 1.069, 95% CI 1.00-1.135, p = .03). CONCLUSION: 
      Multimodal imaging diagnosis of CMD is applicable to HCM patients and is 
      associated with more impaired cardiac function.
CI  - (c) 2024 John Wiley & Sons Ltd.
FAU - Tran, Tien Vuong
AU  - Tran TV
AD  - Department of Cardiology, University Hospital, Grenoble, France.
FAU - Djaileb, Loic
AU  - Djaileb L
AD  - Department of Nuclear Medicine, University Hospital, Grenoble, France.
AD  - Universite Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, Grenoble, France.
FAU - Riou, Laurent
AU  - Riou L
AD  - Universite Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, Grenoble, France.
FAU - Lantuejoul, Lea Ruez
AU  - Lantuejoul LR
AD  - Department of Radiology, University Hospital, Grenoble, France.
FAU - Giai, Joris
AU  - Giai J
AD  - Universite Grenoble Alpes, Inserm CIC1406, CHU Grenoble Alpes, TIMC UMR 5525, 
      Grenoble, France.
FAU - Barone-Rochette, Gilles
AU  - Barone-Rochette G
AUID- ORCID: 0000-0002-1146-0542
AD  - Department of Cardiology, University Hospital, Grenoble, France.
AD  - Universite Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, Grenoble, France.
AD  - FACT (French Alliance for Cardiovascular Clinical Trials), an F-CRIN network, 
      Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - United States
TA  - Microcirculation
JT  - Microcirculation (New York, N.Y. : 1994)
JID - 9434935
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Coronary Circulation
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging
MH  - *Myocardial Ischemia
MH  - Magnetic Resonance Imaging
MH  - Multimodal Imaging
OTO - NOTNLM
OT  - cardiovascular magnetic resonance
OT  - coronary microvascular dysfunction
OT  - hypertrophic cardiomyopathy
OT  - left atrioventricular coupling index
EDAT- 2024/01/04 11:44
MHDA- 2024/02/16 06:43
CRDT- 2024/01/04 05:38
PHST- 2023/12/05 00:00 [revised]
PHST- 2023/08/16 00:00 [received]
PHST- 2023/12/22 00:00 [accepted]
PHST- 2024/02/16 06:43 [medline]
PHST- 2024/01/04 11:44 [pubmed]
PHST- 2024/01/04 05:38 [entrez]
AID - 10.1111/micc.12843 [doi]
PST - ppublish
SO  - Microcirculation. 2024 Feb;31(2):e12843. doi: 10.1111/micc.12843. Epub 2024 Jan 
      4.