PMID- 38174696
OWN - NLM
STAT- MEDLINE
DCOM- 20240117
LR  - 20240121
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 58
IP  - 2
DP  - 2024 Jan 16
TI  - OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease 
      in the Swedish Mammography Cohort.
PG  - 1036-1047
LID - 10.1021/acs.est.3c06388 [doi]
AB  - Cardiovascular disease (CVD) development may be linked to persistent organic 
      pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl 
      and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we 
      investigated metabolites, proteins, and genes linking POPs with CVD risk. We used 
      data from a nested case-control study on myocardial infarction (MI) and stroke 
      from the Swedish Mammography Cohort - Clinical (n = 657 subjects). OCs, PFAS, and 
      multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite 
      features; 248 proteins; 8110 gene variants) were measured in baseline plasma. 
      POP-related omics features were selected using random forest followed by Spearman 
      correlation adjusted for confounders. From these, CVD-related omics features were 
      selected using conditional logistic regression. Finally, 29 (for OCs) and 12 (for 
      PFAS) unique features associated with POPs and CVD. One omics subpattern, driven 
      by lipids and inflammatory proteins, associated with MI (OR = 2.03; 95% CI = 
      1.47; 2.79), OCs, age, and BMI, and correlated negatively with PFAS. Another 
      subpattern, driven by carnitines, associated with stroke (OR = 1.55; 95% CI = 
      1.16; 2.09), OCs, and age, but not with PFAS. This may imply that OCs and PFAS 
      associate with different omics patterns with opposite effects on CVD risk, but 
      more research is needed to disentangle potential modifications by other factors.
FAU - Schillemans, Tessa
AU  - Schillemans T
AUID- ORCID: 0000-0002-1044-1630
AD  - Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm 171 77, Sweden.
FAU - Yan, Yingxiao
AU  - Yan Y
AUID- ORCID: 0000-0002-9196-7326
AD  - Food and Nutrition Sciences, Department of Life Sciences, Chalmers University of 
      Technology, Gothenburg 412 96, Sweden.
FAU - Ribbenstedt, Anton
AU  - Ribbenstedt A
AD  - Food and Nutrition Sciences, Department of Life Sciences, Chalmers University of 
      Technology, Gothenburg 412 96, Sweden.
FAU - Donat-Vargas, Carolina
AU  - Donat-Vargas C
AD  - Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm 171 77, Sweden.
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona 08036, Spain.
FAU - Lindh, Christian H
AU  - Lindh CH
AD  - Division of Occupational and Environmental Medicine, Lund University, Lund 221 
      00, Sweden.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - Department of Health Security, National Institute for Health and Welfare, Kuopio 
      70701, Finland.
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - Department of Health Security, National Institute for Health and Welfare, Kuopio 
      70701, Finland.
FAU - Wolk, Alicja
AU  - Wolk A
AD  - Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm 171 77, Sweden.
FAU - Landberg, Rikard
AU  - Landberg R
AD  - Food and Nutrition Sciences, Department of Life Sciences, Chalmers University of 
      Technology, Gothenburg 412 96, Sweden.
AD  - Department of Public Health and Clinical Medicine, Umea University, Umea 901 87, 
      Sweden.
FAU - Akesson, Agneta
AU  - Akesson A
AD  - Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm 171 77, Sweden.
FAU - Brunius, Carl
AU  - Brunius C
AD  - Food and Nutrition Sciences, Department of Life Sciences, Chalmers University of 
      Technology, Gothenburg 412 96, Sweden.
AD  - Chalmers Mass Spectrometry Infrastructure, Department of Life Sciences, Chalmers 
      University of Technology, Gothenburg 412 96, Sweden.
AD  - Medical Epidemiology, Department of Surgical Sciences, Uppsala University, 
      Uppsala 751 05, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Persistent Organic Pollutants)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Humans
MH  - Persistent Organic Pollutants
MH  - *Cardiovascular Diseases/epidemiology
MH  - Sweden/epidemiology
MH  - Case-Control Studies
MH  - *Environmental Pollutants
MH  - *Hydrocarbons, Chlorinated
MH  - *Fluorocarbons
MH  - *Stroke/epidemiology
PMC - PMC10795192
OTO - NOTNLM
OT  - cardiovascular disease
OT  - genetics
OT  - metabolomics
OT  - multiomics
OT  - nested case-control study
OT  - persistent organic pollutants
OT  - proteomics
COIS- The authors declare no competing financial interest.
EDAT- 2024/01/04 12:43
MHDA- 2024/01/17 06:43
PMCR- 2024/01/18
CRDT- 2024/01/04 07:46
PHST- 2024/01/17 06:43 [medline]
PHST- 2024/01/04 12:43 [pubmed]
PHST- 2024/01/04 07:46 [entrez]
PHST- 2024/01/18 00:00 [pmc-release]
AID - 10.1021/acs.est.3c06388 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2024 Jan 16;58(2):1036-1047. doi: 10.1021/acs.est.3c06388. 
      Epub 2024 Jan 4.