PMID- 38177157
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240117
IS  - 2056-676X (Electronic)
IS  - 2056-676X (Linking)
VI  - 10
IP  - 1
DP  - 2024 Jan 4
TI  - Pulmonary hypertension.
PG  - 1
LID - 10.1038/s41572-023-00486-7 [doi]
AB  - Pulmonary hypertension encompasses a range of conditions directly or indirectly 
      leading to elevated pressures within the pulmonary arteries. Five main groups of 
      pulmonary hypertension are recognized, all defined by a mean pulmonary artery 
      pressure of >20 mmHg: pulmonary arterial hypertension (rare), pulmonary 
      hypertension associated with left-sided heart disease (very common), pulmonary 
      hypertension associated with lung disease (common), pulmonary hypertension 
      associated with pulmonary artery obstructions, usually related to thromboembolic 
      disease (rare), and pulmonary hypertension with unclear and/or multifactorial 
      mechanisms (rare). At least 1% of the world's population is affected, with a 
      greater burden more likely in low-income and middle-income countries. Across all 
      its forms, pulmonary hypertension is associated with adverse vascular remodelling 
      with obstruction, stiffening and vasoconstriction of the pulmonary vasculature. 
      Without proactive management this leads to hypertrophy and ultimately failure of 
      the right ventricle, the main cause of death. In older individuals, dyspnoea is 
      the most common symptom. Stepwise investigation precedes definitive diagnosis 
      with right heart catheterization. Medical and surgical treatments are approved 
      for pulmonary arterial hypertension and chronic thromboembolic pulmonary 
      hypertension. There are emerging treatments for other forms of pulmonary 
      hypertension; but current therapy primarily targets the underlying cause. There 
      are still major gaps in basic, clinical and translational knowledge; thus, 
      further research, with a focus on vulnerable populations, is needed to better 
      characterize, detect and effectively treat all forms of pulmonary hypertension.
CI  - (c) 2024. Springer Nature Limited.
FAU - Mocumbi, Ana
AU  - Mocumbi A
AUID- ORCID: 0000-0002-9564-2860
AD  - Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mocambique. 
      ana.mocumbi@uem.ac.mz.
AD  - Instituto Nacional de Saude, EN 1, Marracuene, Mocambique. ana.mocumbi@uem.ac.mz.
FAU - Humbert, Marc
AU  - Humbert M
AUID- ORCID: 0000-0003-0703-2892
AD  - Service de Pneumologie et Soins Intensifs Respiratoires, Hopital Bicetre 
      (Assistance Publique Hopitaux de Paris), Universite Paris-Saclay, INSERM UMR_S 
      999, Paris, France.
AD  - ERN-LUNG, Le Kremlin Bicetre, Paris, France.
FAU - Saxena, Anita
AU  - Saxena A
AD  - Sharma University of Health Sciences, Haryana, New Delhi, India.
FAU - Jing, Zhi-Cheng
AU  - Jing ZC
AUID- ORCID: 0000-0003-0493-0929
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern 
      Medical University, Guangzhou, China.
FAU - Sliwa, Karen
AU  - Sliwa K
AD  - Cape Heart Institute, Faculty of Health Science, University of Cape Town, Cape 
      Town, South Africa.
FAU - Thienemann, Friedrich
AU  - Thienemann F
AUID- ORCID: 0000-0002-4801-2030
AD  - Department of Medicine, Groote Schuur Hospital, Faculty of Health Science, 
      University of Cape Town, Cape Town, South Africa.
AD  - Department of Internal Medicine, University Hospital Zurich, University of 
      Zurich, Zurich, Switzerland.
FAU - Archer, Stephen L
AU  - Archer SL
AD  - Department of Medicine, Queen's University, Kingston, Ontario, Canada.
FAU - Stewart, Simon
AU  - Stewart S
AUID- ORCID: 0000-0001-9032-8998
AD  - Institute of Health Research, University of Notre Dame, Fremantle, Western 
      Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240104
PL  - England
TA  - Nat Rev Dis Primers
JT  - Nature reviews. Disease primers
JID - 101672103
SB  - IM
EIN - Nat Rev Dis Primers. 2024 Jan 17;10(1):5. PMID: 38233482
MH  - Humans
MH  - Aged
MH  - *Hypertension, Pulmonary/diagnosis/epidemiology/etiology
MH  - *Pulmonary Arterial Hypertension/complications
MH  - Pulmonary Artery
MH  - Lung
EDAT- 2024/01/05 00:42
MHDA- 2024/01/08 06:43
CRDT- 2024/01/04 23:17
PHST- 2023/11/27 00:00 [accepted]
PHST- 2024/01/08 06:43 [medline]
PHST- 2024/01/05 00:42 [pubmed]
PHST- 2024/01/04 23:17 [entrez]
AID - 10.1038/s41572-023-00486-7 [pii]
AID - 10.1038/s41572-023-00486-7 [doi]
PST - epublish
SO  - Nat Rev Dis Primers. 2024 Jan 4;10(1):1. doi: 10.1038/s41572-023-00486-7.