PMID- 38178744
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240108
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 53
IP  - 1
DP  - 2024 Jan 8
TI  - [Follicular lymphoma with a predominantly diffuse growth pattern with 1p36 
      deletion: a clinicopathologic analysis of eight cases].
PG  - 34-39
LID - 10.3760/cma.j.cn112151-20230905-00130 [doi]
AB  - Objective: To investigate the clinical and pathologic features and diagnosis of 
      follicular lymphoma (FL) with a predominantly diffuse growth pattern (DFL) with 
      1p36 deletion. Methods: Eight cases of DFL with 1p36 deletion diagnosed at 
      Department of Pathology, Beijing Friendship Hospital, Capital Medical University 
      (n=5) and the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer 
      Hospital (n=3) from January 2017 to January 2023 were included. Their 
      clinicopathologic features and follow-up data were analyzed. Immunohistochemistry 
      and fluorescence in situ hybridization (FISH) were performed. Results: There were 
      five males and three females, with a median age of 67 years, and inguinal 
      lymphadenopathy was found as the main symptom. Histologically, similar 
      morphologic features were sheared among all cases, with effaced nodal structure 
      and characterized by proliferation of centrocytes in a diffuse pattern, with or 
      without follicular components. The germinal center-related markers such as CD10 
      and/or bcl-6 were expressed in the tumor cells, and 1p36 deletion but not bcl-2 
      translocation was appreciable in these cases. Conclusions: DFL with 1p36 deletion 
      is a rare subtype of FL, with some overlaps with other types of FL or indolent 
      B-cell lymphomas in their pathologic features. An accurate diagnosis requires 
      comprehensive considerations based on their clinical, pathologic, 
      immunohistochemical, and molecular features.
FAU - Zhou, J
AU  - Zhou J
AD  - Department of Pathology, the Affiliated Cancer Hospital of Zhengzhou University, 
      Henan Cancer Hospital, Zhengzhou 450008, China.
FAU - Xie, J L
AU  - Xie JL
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Zhou, X G
AU  - Zhou XG
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100020, China.
FAU - Zhou, X J
AU  - Zhou XJ
AD  - Department of Pathology, the Affiliated Cancer Hospital of Zhengzhou University, 
      Henan Cancer Hospital, Zhengzhou 450008, China.
FAU - Xia, Q X
AU  - Xia QX
AD  - Department of Pathology, the Affiliated Cancer Hospital of Zhengzhou University, 
      Henan Cancer Hospital, Zhengzhou 450008, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Aged
MH  - *Lymphoma, Follicular/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphoma, B-Cell/pathology
MH  - Chromosome Deletion
MH  - Cell Proliferation
EDAT- 2024/01/05 06:42
MHDA- 2024/01/08 06:43
CRDT- 2024/01/05 03:15
PHST- 2024/01/08 06:43 [medline]
PHST- 2024/01/05 06:42 [pubmed]
PHST- 2024/01/05 03:15 [entrez]
AID - 10.3760/cma.j.cn112151-20230905-00130 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2024 Jan 8;53(1):34-39. doi: 
      10.3760/cma.j.cn112151-20230905-00130.