PMID- 38178893
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240106
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - A localized pallidal physiomarker in Meige syndrome.
PG  - 1286634
LID - 10.3389/fneur.2023.1286634 [doi]
LID - 1286634
AB  - OBJECTIVES: Oscillatory patterns in local field potentials (LFPs) have been 
      recognized as disease-specific physiomarkers, particularly in the context of 
      Parkinson's disease and cervical dystonia. This characteristic oscillatory 
      feature is currently employed in adaptive deep brain stimulation (aDBS). However, 
      for other types of dystonia, especially Meige syndrome, a distinct physiomarker 
      of this nature is yet to be identified. METHODS: Local field potentials were 
      recorded during microelectrode-guided deep brain stimulation surgery from 28 
      patients with primary Meige syndrome. Before surgery, the severity of patients' 
      motor syndrome were assessed using the Burke-Fahn-Marsden Dystonia Rating 
      Scale-Motor (BFMDRS-M). An instantaneous oscillation detection method was 
      employed to identify true narrowband oscillations. Subsequently, a linear mixed 
      effects model was utilized to examine the relationship between oscillatory 
      activities (including power amplitude and burst duration) and symptom severity. 
      RESULTS: The focal peaks of "oscillatory activities" detected were predominantly 
      concentrated in the narrow theta band (4-8 Hz), constituting 81.5% of the total 
      detected oscillations in all recording sites near active DBS contacts in the 
      globus pallidus internus (GPi). The linear mixed effects model revealed a 
      positive correlation between the theta burst duration and the severity of 
      preoperative motor impairment, but no correlation with postoperative motor 
      scores. Additionally, there was no significant lateralization effect observed 
      between the left and right GPi. CONCLUSION: Our findings suggest that the 
      exaggerated narrowband theta activity (mainly the burst duration) in the GPi is 
      predictive of dystonia symptom severity and may be used as a physiomarker for 
      optimized DBS target during surgery and adaptive DBS for the treatment of Meige 
      syndrome.
CI  - Copyright (c) 2023 Zhang, Tian, Yu, Zhen, Zhang, Yuan and Wang.
FAU - Zhang, Bo
AU  - Zhang B
AD  - Key Laboratory of Brain Science, Zunyi Medical University, Zunyi, China.
AD  - Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical 
      University, Zunyi, China.
FAU - Tian, Hong
AU  - Tian H
AD  - Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
FAU - Yu, Yanbing
AU  - Yu Y
AD  - Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhen, Xueke
AU  - Zhen X
AD  - Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
FAU - Yuan, Yue
AU  - Yuan Y
AD  - Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
FAU - Wang, Liang
AU  - Wang L
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20231221
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10764606
OTO - NOTNLM
OT  - Meige syndrome
OT  - deep brain stimulation
OT  - globus pallidus internus
OT  - local field potentials
OT  - theta oscillations
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/05 06:42
MHDA- 2024/01/05 06:43
PMCR- 2023/12/21
CRDT- 2024/01/05 03:46
PHST- 2023/08/31 00:00 [received]
PHST- 2023/12/06 00:00 [accepted]
PHST- 2024/01/05 06:43 [medline]
PHST- 2024/01/05 06:42 [pubmed]
PHST- 2024/01/05 03:46 [entrez]
PHST- 2023/12/21 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1286634 [doi]
PST - epublish
SO  - Front Neurol. 2023 Dec 21;14:1286634. doi: 10.3389/fneur.2023.1286634. 
      eCollection 2023.