PMID- 38179659 OWN - NLM STAT- Publisher LR - 20240105 IS - 1469-8978 (Electronic) IS - 0033-2917 (Linking) DP - 2024 Jan 5 TI - The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis. PG - 1-9 LID - 10.1017/S0033291723003598 [doi] AB - BACKGROUND: Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in PEs lead to social withdrawal, which, subsequently, triggers PEs at a next point in time, especially when SI is associated with increased distress. The current study investigated the daily-life temporal associations between SI and PEs, as well as the role of SI-related and general affective distress in individuals at clinical high risk (CHR) for psychosis. METHODS: We used experience sampling methodology in a sample of 137 CHR participants. We analyzed the association between SI, PEs, and distress using time-lagged linear mixed-effects models. RESULTS: SI did not predict next-moment fluctuations in PEs, or vice versa. Furthermore, although SI-related distress was not predictive of subsequent PEs, general affective distress during SI was a robust predictor of next-moment PEs. CONCLUSIONS: Our results suggest that SI and PEs are not directly related on a moment-to-moment level, but a negative emotional state when alone does contribute to the risk of PEs. These findings highlight the role of affective wellbeing during early-stage psychosis development. FAU - Akcaoglu, Zeynep AU - Akcaoglu Z AUID- ORCID: 0000-0002-8619-6301 AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. FAU - Vaessen, Thomas AU - Vaessen T AUID- ORCID: 0000-0002-9300-3117 AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. AD - Department of Psychology, Health & Technology, Faculty of Behavioural, Management and Social Sciences (BMS), University of Twente, Enschede, The Netherlands. FAU - Velthorst, Eva AU - Velthorst E AD - Department of Research, Community Mental Health Service GGZ Noord-Holland-Noord, Heerhugowaard, The Netherlands. FAU - Lafit, Ginette AU - Lafit G AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. AD - Faculty of Psychology and Educational Sciences, Research Group of Quantitative Psychology and Individual Differences, KU Leuven, Leuven, Belgium. FAU - Achterhof, Robin AU - Achterhof R AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. FAU - Nelson, Barnaby AU - Nelson B AD - Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia. AD - Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia. FAU - McGorry, Patrick AU - McGorry P AD - Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia. FAU - Schirmbeck, Frederike AU - Schirmbeck F AD - Department of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, North Holland, Netherlands. AD - Arkin, Institute for Mental Health, Amsterdam, North Holland, The Netherlands. CN - EU-GEI High Risk Study FAU - Morgan, Craig AU - Morgan C AD - ESRC Centre for Society and Mental Health and Social Epidemiology Research Group, King's College London, London, London, UK. AD - Health Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Hartmann, Jessica AU - Hartmann J AD - Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia. AD - Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wurttemberg, Germany. FAU - van der Gaag, Mark AU - van der Gaag M AD - Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, North Holland, The Netherlands. AD - Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, South Holland, The Netherlands. FAU - de Haan, Lieuwe AU - de Haan L AD - Department of Early Psychosis, Amsterdam UMC, Location AMC, Amsterdam, North Holland, The Netherlands. FAU - Valmaggia, Lucia AU - Valmaggia L AD - Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. AD - NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK. FAU - McGuire, Philip AU - McGuire P AD - NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK. FAU - Kempton, Matthew AU - Kempton M AD - Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, London, UK. FAU - Steinhart, Henrietta AU - Steinhart H AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Klippel, Annelie AU - Klippel A AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. AD - Department of Lifespan Psychology, Faculty of Psychology, Open University, Heerlen, The Netherlands. FAU - Viechtbauer, Wolfgang AU - Viechtbauer W AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Batink, Tim AU - Batink T AD - Department of Lifespan Psychology, Faculty of Psychology, Open University, Heerlen, The Netherlands. FAU - van Winkel, Ruud AU - van Winkel R AD - Department of Neurosciences, Psychiatry Research Group, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium. FAU - van Amelsvoort, Therese AU - van Amelsvoort T AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Marcelis, Machteld AU - Marcelis M AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. AD - Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, The Netherlands, https://www.ggze.nl/. FAU - van Aubel, Evelyne AU - van Aubel E AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. FAU - Reininghaus, Ulrich AU - Reininghaus U AD - ESRC Centre for Society and Mental Health and Social Epidemiology Research Group, King's College London, London, London, UK. AD - Health Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wurttemberg, Germany. FAU - Myin-Germeys, Inez AU - Myin-Germeys I AD - Department of Neurosciences, Psychiatry Research Group, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium. LA - eng GR - 309767 - INTERACT/ERC_/European Research Council/International PT - Journal Article DEP - 20240105 PL - England TA - Psychol Med JT - Psychological medicine JID - 1254142 SB - IM OTO - NOTNLM OT - clinical high-risk OT - distress OT - experience sampling methodology OT - negative affect OT - psychotic experiences OT - social isolation OT - solitary stress EDAT- 2024/01/05 06:43 MHDA- 2024/01/05 06:43 CRDT- 2024/01/05 04:23 PHST- 2024/01/05 06:43 [medline] PHST- 2024/01/05 06:43 [pubmed] PHST- 2024/01/05 04:23 [entrez] AID - S0033291723003598 [pii] AID - 10.1017/S0033291723003598 [doi] PST - aheadofprint SO - Psychol Med. 2024 Jan 5:1-9. doi: 10.1017/S0033291723003598.