PMID- 38180331
OWN - NLM
STAT- Publisher
LR  - 20240105
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
DP  - 2024 Jan 5
TI  - Fc-gamma receptor expression and cytokine responses to intravenous human 
      immunoglobulin in whole blood from non-pregnant and pregnant women and newborns.
LID - 10.17219/acem/174566 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) can suppress the inflammatory 
      response in adults, but its role in pregnant women and newborns is poorly 
      studied. While the adult immune system is considered mature, it is immature in 
      neonates and suppressed in pregnancy. Since the immune response differs in these 
      3 groups, the use of IVIG could differentially modulate the immune response. 
      OBJECTIVES: We aimed to explore the effect of IVIG on myeloid blood cells from 
      non-pregnant women, pregnant women and newborns. MATERIAL AND METHODS: Whole 
      blood from healthy donors was incubated with lipopolysaccharide (LPS) and/or 
      IVIG. After 0 h, 24 h and 48 h of culture, Fc-gamma receptor (CD16, CD32 and 
      CD64) expression, monocyte and neutrophil bacterial phagocytosis, and cytokine 
      and chemokine concentrations were determined in the supernatant. RESULTS: The 
      baseline expression of monocyte CD16 was higher in newborns than in adult women, 
      but the expression of CD32 and CD64 was similar between groups. Furthermore, LPS 
      and IVIG stimulation, together or separately, did not change Fc-gamma receptor 
      expression in monocytes or neutrophils and did not modify their phagocytosis 
      capacity. On the other hand, IVIG did not downregulate the proinflammatory 
      cytokine response induced by LPS in any group. Interestingly, IVIG induced a 
      strong interleukin 8 (IL-8) response in neonates but not in non-pregnant or 
      pregnant women. CONCLUSIONS: Our results show that IVIG did not induce changes in 
      Fc-gamma receptor expression, phagocytic ability, or the cytokine response to LPS 
      in blood cells from neonates, non-pregnant or pregnant women. However, IVIG 
      induced a strong IL-8 response in neonates that could improve immunity.
FAU - Vazquez-Rodriguez, Stephania
AU  - Vazquez-Rodriguez S
AD  - Department of Physiology and Cellular Development, National Institute of 
      Perinatology (INPer), Mexico City, Mexico.
AD  - Department of Immunology, National School of Biomedical Sciences, Mexico City, 
      Mexico.
FAU - Arriaga-Pizano, Lourdes A
AU  - Arriaga-Pizano LA
AD  - School of Dentistry, Benito Juarez Autonomous University of Oaxaca, Mexico.
AD  - Medical Research Unit in Immunochemistry, Specialty Hospital "Dr. Bernardo 
      Sepulveda Gutierrez", Mexico City, Mexico.
FAU - Mancilla-Herrera, Ismael
AU  - Mancilla-Herrera I
AD  - Department of Infectious Diseases and Immunology, National Institute of 
      Perinatology (INPer), Mexico City, Mexico.
FAU - Prieto-Chavez, Jessica
AU  - Prieto-Chavez J
AD  - Department of Immunology, National School of Biomedical Sciences, Mexico City, 
      Mexico.
AD  - Medical Research Unit in Immunochemistry, Specialty Hospital "Dr. Bernardo 
      Sepulveda Gutierrez", Mexico City, Mexico.
FAU - Arizmendi-Villanueva, Roberto
AU  - Arizmendi-Villanueva R
AD  - Women's Hospital, Secretariat of Health, Mexico City, Mexico.
FAU - Torres-Rosas, Rafael
AU  - Torres-Rosas R
AD  - School of Dentistry, Benito Juarez Autonomous University of Oaxaca, Mexico.
FAU - Flisser, Ana
AU  - Flisser A
AD  - Faculty of Medicine, Department of Microbiology and Parasitology, National 
      Autonomous University of Mexico (UNAM), Mexico City, Mexico.
FAU - Garcia-Latorre, Ethel
AU  - Garcia-Latorre E
AD  - Department of Immunology, National School of Biomedical Sciences, Mexico City, 
      Mexico.
FAU - Cerbulo-Vazquez, Arturo
AU  - Cerbulo-Vazquez A
AD  - Genomic Medicine Service, General Hospital of Mexico "Dr. Eduardo Liceaga", 
      Mexico City, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20240105
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical 
      University
JID - 101138582
SB  - IM
OTO - NOTNLM
OT  - Fc-gamma receptors
OT  - IVIG
OT  - maternal-newborn response
EDAT- 2024/01/05 12:43
MHDA- 2024/01/05 12:43
CRDT- 2024/01/05 09:58
PHST- 2023/05/02 00:00 [received]
PHST- 2023/06/20 00:00 [revised]
PHST- 2023/10/26 00:00 [accepted]
PHST- 2024/01/05 12:43 [medline]
PHST- 2024/01/05 12:43 [pubmed]
PHST- 2024/01/05 09:58 [entrez]
AID - 10.17219/acem/174566 [doi]
PST - aheadofprint
SO  - Adv Clin Exp Med. 2024 Jan 5. doi: 10.17219/acem/174566.