PMID- 38180371
OWN - NLM
STAT- MEDLINE
DCOM- 20240109
LR  - 20240109
IS  - 1561-9125 (Print)
IS  - 1561-9125 (Linking)
VI  - 36
IP  - 5
DP  - 2023
TI  - [Age-related changes in AKT and mTOR expression in mediobasal hypothalamus 
      neurons with aging.].
PG  - 714-719
AB  - The hypothalamus is a regulatory center that controls homeostasis, reproduction, 
      circadian rhythms, and the endocrine system. It is also involved in the 
      regulation of aging. Expression of protein kinase B (AKT), the mammalian target 
      of rapamycin (mTOR), and phosphorylated forms of AKT (pAKT) and mTOR (pmTOR) was 
      studied by Western blotting in 3-, 12-, and 24-month-old male rats in the arcuate 
      (ARN), dorsomedial (DMN) and ventromedial (VMN) nuclei of the hypothalamus. The 
      results showed that the components of AKT/mTOR signaling change differently in 
      the mediobasal hypothalamic nuclei of rats with age. The expression of AKT and 
      pAKT decreased in the ARN, DMN, and VMN with aging; the expression of mTOR and 
      pmTOR increased in the ARN, but decreased in the DMN and VMN in aged rats. The 
      results obtained can serve as a basis for future studies of the mechanisms of 
      age-related diseases and their pharmacological treatment.
FAU - Anfimova, P A
AU  - Anfimova PA
AD  - Yaroslavl State Medical University, 5 Revolucionnaya str., Yaroslavl 150000, 
      Russian Federation, e-mail: mpm@ysmu.ru.
FAU - Pankrasheva, L G
AU  - Pankrasheva LG
AD  - Yaroslavl State Medical University, 5 Revolucionnaya str., Yaroslavl 150000, 
      Russian Federation, e-mail: mpm@ysmu.ru.
FAU - Moiseev, K Y
AU  - Moiseev KY
AD  - Yaroslavl State Medical University, 5 Revolucionnaya str., Yaroslavl 150000, 
      Russian Federation, e-mail: mpm@ysmu.ru.
FAU - Emanuylov, A I
AU  - Emanuylov AI
AD  - Yaroslavl State Medical University, 5 Revolucionnaya str., Yaroslavl 150000, 
      Russian Federation, e-mail: mpm@ysmu.ru.
FAU - Porseva, V V
AU  - Porseva VV
AD  - Yaroslavl State Medical University, 5 Revolucionnaya str., Yaroslavl 150000, 
      Russian Federation, e-mail: mpm@ysmu.ru.
FAU - Masliukov, P M
AU  - Masliukov PM
AD  - Yaroslavl State Medical University, 5 Revolucionnaya str., Yaroslavl 150000, 
      Russian Federation, e-mail: mpm@ysmu.ru.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Adv Gerontol
JT  - Advances in gerontology = Uspekhi gerontologii
JID - 100971443
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - W36ZG6FT64 (Sirolimus)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Male
MH  - Rats
MH  - Aging/genetics
MH  - Hypothalamus
MH  - Neurons
MH  - *Proto-Oncogene Proteins c-akt
MH  - Sirolimus
MH  - *TOR Serine-Threonine Kinases
OTO - NOTNLM
OT  - AKT
OT  - aging
OT  - hypothalamus
OT  - mTOR
EDAT- 2024/01/05 12:43
MHDA- 2024/01/08 06:42
CRDT- 2024/01/05 10:13
PHST- 2024/01/08 06:42 [medline]
PHST- 2024/01/05 12:43 [pubmed]
PHST- 2024/01/05 10:13 [entrez]
PST - ppublish
SO  - Adv Gerontol. 2023;36(5):714-719.