PMID- 38180518
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240221
IS  - 2731-698X (Electronic)
IS  - 2731-6971 (Linking)
VI  - 95
IP  - 3
DP  - 2024 Mar
TI  - [Individualized approach for MEN1-associated duodenopancreatic neuroendocrine 
      neoplasms].
PG  - 207-215
LID - 10.1007/s00104-023-01994-8 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1)-associated 
      duodenopancreatic neuroendocrine neoplasms (dpNEN) represent the most frequent 
      syndrome-associated cause of death, but the adequate treatment is sometimes 
      considered controversial. OBJECTIVE: Presentation of possible diagnostic and 
      therapeutic options for MEN1-associated dpNENs. MATERIAL AND METHODS: In this 
      review article retrospective case studies, expert recommendations, national and 
      international guidelines as well as personal experiences were analyzed and 
      evaluated. RESULTS: Due to early detection programs and the use of the most 
      modern imaging techniques, dpNEN are nowadays diagnosed much earlier. 
      Nonfunctional pNENs currently represent the most frequent dpNENs with about 70%, 
      followed by gastrinomas and insulinomas. Regardless of their functional activity, 
      dpNENs with a size of > 2 cm are generally an indication for surgery. The choice 
      of the optimal treatment strategy, however, in most cases remains the subject of 
      controversial discussions, although nowadays surgery should always be performed 
      in an organ-preserving and minimally invasive way when feasible. Recurrences or 
      new dpNENs are expected in more than 60% of cases, necessitating a reoperation in 
      up to 40% of these cases. Duodenopancreatic resections and reoperations can be 
      carried out safely by experienced practitioners and with an acceptable level of 
      risk. CONCLUSION: The planning of treatment requires careful consideration of the 
      suitable timing, the extent of the operation, the risk of recurrence and 
      potential morbidities. Furthermore, preserving pancreatic function and the 
      quality of life is of utmost importance. In view of the complexity of the 
      disease, MEN1 patients should be treated in specialized centers.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, 
      ein Teil von Springer Nature.
FAU - Manoharan, Jerena
AU  - Manoharan J
AD  - Klinik fur Visceral‑, Thorax- und Gefasschirurgie, Philipps Universitat Marburg, 
      35043, Marburg, Deutschland. jerena.manoharan@uk-gm.de.
FAU - Albers, Max B
AU  - Albers MB
AD  - Klinik fur Visceral‑, Thorax- und Gefasschirurgie, Philipps Universitat Marburg, 
      35043, Marburg, Deutschland.
FAU - Bartsch, Detlef K
AU  - Bartsch DK
AD  - Klinik fur Visceral‑, Thorax- und Gefasschirurgie, Philipps Universitat Marburg, 
      35043, Marburg, Deutschland.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Individualisiertes Vorgehen bei MEN1-assoziierten duodenopankreatischen 
      neuroendokrinen Neoplasien.
DEP - 20240105
PL  - Germany
TA  - Chirurgie (Heidelb)
JT  - Chirurgie (Heidelberg, Germany)
JID - 9918383081906676
SB  - IM
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/diagnosis/genetics/surgery
MH  - Retrospective Studies
MH  - Quality of Life
MH  - *Pancreatic Neoplasms/diagnosis/genetics/surgery
MH  - *Insulinoma/surgery
OTO - NOTNLM
OT  - Functional pancreatic neuroendocrine neoplasms
OT  - Multiple endocrine neoplasia type 1
OT  - Nonfunctional pancreatic neuroendocrine neoplasms
OT  - Screening
OT  - Syndrome-associated cause of death
EDAT- 2024/01/05 12:43
MHDA- 2024/02/21 11:15
CRDT- 2024/01/05 11:05
PHST- 2023/10/26 00:00 [accepted]
PHST- 2024/02/21 11:15 [medline]
PHST- 2024/01/05 12:43 [pubmed]
PHST- 2024/01/05 11:05 [entrez]
AID - 10.1007/s00104-023-01994-8 [pii]
AID - 10.1007/s00104-023-01994-8 [doi]
PST - ppublish
SO  - Chirurgie (Heidelb). 2024 Mar;95(3):207-215. doi: 10.1007/s00104-023-01994-8. 
      Epub 2024 Jan 5.