PMID- 38183083 OWN - NLM STAT- MEDLINE DCOM- 20240108 LR - 20240117 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jan 5 TI - Burden of type 2 diabetes mellitus and its risk factors in North Africa and the Middle East, 1990-2019: findings from the Global Burden of Disease study 2019. PG - 98 LID - 10.1186/s12889-023-16540-8 [doi] LID - 98 AB - BACKGROUND: The prevalence of Type 2 Diabetes Mellitus (T2DM) in the North Africa and Middle East region is alarmingly high, prompting us to investigate the burden and factors contributing to it through the GBD study. Additionally, there is a lack of knowledge about the epidemiological status of T2DM in this region, so our aim is to provide a comprehensive overview of the burden of T2DM and its associated risk factors. METHODS: Using data from the 2019 Global Burden of Disease Study, we calculated the attributable burden of T2DM for each of the 21 countries in the region for the years 1990 and 2019. This included prevalence, mortality, disability-adjusted life years (DALYs), and risk factors. RESULTS: Between 1990 and 2019, there was a significant increase in the age-standardized incidence (79.6%; 95% Uncertainty Interval: 75.0 to 84.5) and prevalence (85.5%; [80.8 to 90.3]) rates of T2DM per 100,000 populations. The age-standardized mortality rate (1.7%; [-10.4 to 14.9]), DALYs (31.2%; [18.3 to 42.2]), and years lived with disability (YLDs) (82.6%; [77.2 to 88.1]) also increased during this period. Modifiable risk factors, such as high body mass index (56.4%; [42.8 to 69.8]), low physical activity (15.5%; [9.0 to 22.8]), and ambient particulate matter pollution (20.9%; [15.2 to 26.2]), were the main contributors to the number of deaths. CONCLUSION: The burden of T2DM, in terms of mortality, DALYs, and YLDs, continues to rise in the region. The incidence rate of T2DM has increased in many areas. The burden of T2DM attributed to modifiable risk factors continues to grow in most countries. Targeting these modifiable risk factors could effectively reduce the growth and disease burden of T2DM in the region. CI - (c) 2024. The Author(s). FAU - Namazi, Nazli AU - Namazi N AD - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Moghaddam, Sahar Saeedi AU - Moghaddam SS AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Esmaeili, Shahnaz AU - Esmaeili S AD - Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Peimani, Maryam AU - Peimani M AD - Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism, Molecular Cellular Sciences Institute, Tehran University of Medical Science, Tehran, Iran. FAU - Tehrani, Yeganeh Sharifnejad AU - Tehrani YS AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Bandarian, Fatemeh AU - Bandarian F AD - Metabolomics and Genomics Research Center Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Shobeiri, Parnian AU - Shobeiri P AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Nasli-Esfahani, Ensieh AU - Nasli-Esfahani E AD - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. n.nasli@yahoo.com. FAU - Malekpour, Mohammad-Reza AU - Malekpour MR AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Rezaei, Negar AU - Rezaei N AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Rezaei, Nazila AU - Rezaei N AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Arjmand, Babak AU - Arjmand B AD - Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran, Iran. FAU - Larijani, Bagher AU - Larijani B AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. larijanib1340@gmail.com. FAU - Farzadfar, Farshad AU - Farzadfar F AD - Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PT - Review DEP - 20240105 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology MH - Global Burden of Disease MH - Risk Factors MH - Africa, Northern/epidemiology MH - Middle East/epidemiology PMC - PMC10768242 OTO - NOTNLM OT - Burden OT - GBD OT - Risk factors OT - T2DM COIS- The authors declare that they have no competing interest. EDAT- 2024/01/06 10:42 MHDA- 2024/01/08 06:43 PMCR- 2024/01/05 CRDT- 2024/01/05 23:48 PHST- 2022/09/25 00:00 [received] PHST- 2023/08/16 00:00 [accepted] PHST- 2024/01/08 06:43 [medline] PHST- 2024/01/06 10:42 [pubmed] PHST- 2024/01/05 23:48 [entrez] PHST- 2024/01/05 00:00 [pmc-release] AID - 10.1186/s12889-023-16540-8 [pii] AID - 16540 [pii] AID - 10.1186/s12889-023-16540-8 [doi] PST - epublish SO - BMC Public Health. 2024 Jan 5;24(1):98. doi: 10.1186/s12889-023-16540-8.