PMID- 38183085
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240108
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 20
IP  - 1
DP  - 2024 Jan 5
TI  - Spirulina platensis as a growth booster for broiler; Insights into their 
      nutritional, molecular, immunohistopathological, and microbiota modulating 
      effects.
PG  - 11
LID - 10.1186/s12917-023-03858-z [doi]
LID - 11
AB  - BACKGROUND: The present study is designed to assess the effect of adding various 
      doses of Spirulina platensis (SP) on broiler chicken growth performance, gut 
      health, antioxidant biomarkers, cecal microbiota, histopathology, and 
      immunohistochemistry of inducible nitric oxide synthase (iNOS). 240 male Cobb 500 
      broiler chicks (1 day old) were placed into four groups (sixty birds/group), then 
      each group was further divided into three replicates of 20 chickens each for 35 
      days. Birds were allocated as follows; the 1st group (G1), the control group, fed 
      on basal diet, the 2nd group (G2): basal diet plus SP (0.1%), the 3rd group (G3): 
      basal diet plus SP (0.3%), and the 4th group (G4): basal diet plus SP (0.5%). 
      RESULTS: Throughout the trial (d 1 to 35), SP fortification significantly 
      increased body weight growth (BWG) and feed conversion rate (FCR) (P < 0.05). 
      Bursa considerably increased among the immunological organs in the 
      Spirulina-supplemented groups. Within SP-supplemented groups, there was a 
      substantial increase in catalase activity, blood total antioxidant capacity, 
      jejunal superoxide dismutase (SOD), and glutathione peroxidase (GPX) activity 
      (P < 0.05). Fatty acid binding protein 2 (FABP2), one of the gut barrier health 
      biomarkers, significantly increased in the SP-supplemented groups but the IL-1beta 
      gene did not significantly differ across the groups (P < 0.05). Different organs 
      in the control group showed histopathological changes, while the SP-supplemented 
      chicken showed fewer or no signs of these lesions. The control group had higher 
      levels of iNOS expression in the gut than the SP-supplemented groups (p < 0.05). 
      Cecal Lactobacillus count significantly elevated with increasing the rate of SP 
      inclusion rate (p < 0.05). CONCLUSION: Supplementing broiler diets with SP, 
      particularly at 0.5%, can improve productivity and profitability by promoting 
      weight increase, feed utilization, antioxidant status, immunity, and 
      gastrointestinal health.
CI  - (c) 2023. The Author(s).
FAU - Abdelfatah, Samar H
AU  - Abdelfatah SH
AD  - Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, 
      Cairo, University, Giza, 12211, Egypt.
FAU - Yassin, Aya M
AU  - Yassin AM
AD  - Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, 
      Cairo University, Giza, 12211, Egypt. ayamohye@cu.edu.eg.
FAU - Khattab, Marwa S
AU  - Khattab MS
AD  - Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 
      12211, Egypt.
FAU - Abdel-Razek, Ahmed S
AU  - Abdel-Razek AS
AD  - Microbial Chemistry Department, Genetic Engineering and Biotechnology Research 
      Division, National Research Center, Dokki-Giza, Egypt.
FAU - Saad, Adel H
AU  - Saad AH
AD  - Nutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, 
      Matrouh University, Matrouh, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20240105
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - Arthrospira platensis
SB  - IM
MH  - Animals
MH  - Male
MH  - *Antioxidants
MH  - Chickens
MH  - *Spirulina
MH  - Decapodiformes
MH  - Biomarkers
PMC - PMC10768351
OTO - NOTNLM
OT  - And Antioxidant
OT  - Broiler
OT  - Growth performance
OT  - Gut health biomarker
OT  - Spirulina platensis
COIS- The authors declare no competing interests.
EDAT- 2024/01/06 10:41
MHDA- 2024/01/08 06:43
PMCR- 2024/01/05
CRDT- 2024/01/05 23:48
PHST- 2023/06/30 00:00 [received]
PHST- 2023/12/18 00:00 [accepted]
PHST- 2024/01/08 06:43 [medline]
PHST- 2024/01/06 10:41 [pubmed]
PHST- 2024/01/05 23:48 [entrez]
PHST- 2024/01/05 00:00 [pmc-release]
AID - 10.1186/s12917-023-03858-z [pii]
AID - 3858 [pii]
AID - 10.1186/s12917-023-03858-z [doi]
PST - epublish
SO  - BMC Vet Res. 2024 Jan 5;20(1):11. doi: 10.1186/s12917-023-03858-z.