PMID- 3818313
OWN - NLM
STAT- MEDLINE
DCOM- 19870422
LR  - 20211203
IS  - 0883-2897 (Print)
IS  - 0883-2897 (Linking)
VI  - 13
IP  - 5
DP  - 1986
TI  - Radionuclide cholescintigraphic imaging: an evaluation of several 99mTc labelled 
      hepatobiliary radiopharmaceuticals.
PG  - 509-14
AB  - Recently, much interest has been shown in the development of 99mTc labelled 
      cholescintigraphic agents for imaging the hepatobiliary tract. In this study six 
      cholescintigraphic agents were compared in rabbits with respect to transit 
      efficiency through the liver and the halftime on the washout portion of the liver 
      time-activity curve. The agents compared were p-butyl-IDA (PBIDA), 
      diisopropyl-IDA (DISIDA), two mebrofenin (MBF) agents and two pyridoxylaminates 
      (PDA). Best transit efficiencies were obtained with MBF (34.1 and 31.2%) followed 
      by PDA (27.7 and 24.9%) while DISIDA (23%) and PBIDA (19.3%) were the lowest. The 
      same phenomenon was observed regarding the washout halftime, with MBF the most 
      rapid (6.3 and 5.9 min), PDA more prolonged (10.1 and 12.0 min) and DISIDA and 
      PBIDA the slowest (23.0 and 23.2 min). This study confirms the difference in 
      physiological behaviour of the various cholescintigraphic agents and shows 
      identical flow patterns for locally produced and imported compounds.
FAU - van Aswegen, A
AU  - van Aswegen A
FAU - van Wyk, J
AU  - van Wyk J
FAU - Roodt, J P
AU  - Roodt JP
FAU - Lotter, M G
AU  - Lotter MG
FAU - Otto, A C
AU  - Otto AC
FAU - Minnaar, P C
AU  - Minnaar PC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Int J Rad Appl Instrum B
JT  - International journal of radiation applications and instrumentation. Part B, 
      Nuclear medicine and biology
JID - 8611098
RN  - 0 (Aniline Compounds)
RN  - 0 (Imino Acids)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (technetium Tc 99m (Sn)-pyridoxylidenetryptophan)
RN  - 0 (technetium Tc 99m (para-butyl)iminodiacetic acid)
RN  - 7440-26-8 (Technetium)
RN  - 8DUH1N11BX (Tryptophan)
RN  - F2NQ468L52 (technetium Tc 99m mebrofenin)
RN  - QTJ2VIW97T (Technetium Tc 99m Disofenin)
RN  - TE7660XO1C (Glycine)
SB  - IM
EIN - Int J Rad Appl Instrum [B] 1987;14(2):164
MH  - Aniline Compounds
MH  - Animals
MH  - Gallbladder/*diagnostic imaging
MH  - Glycine
MH  - *Imino Acids
MH  - Indicators and Reagents
MH  - Kinetics
MH  - Liver/*diagnostic imaging/metabolism
MH  - Organometallic Compounds
MH  - *Organotechnetium Compounds
MH  - Rabbits
MH  - Radionuclide Imaging
MH  - Structure-Activity Relationship
MH  - *Technetium
MH  - Technetium Tc 99m Disofenin
MH  - Tryptophan/analogs & derivatives
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1016/0883-2897(86)90129-7 [doi]
PST - ppublish
SO  - Int J Rad Appl Instrum B. 1986;13(5):509-14. doi: 10.1016/0883-2897(86)90129-7.