PMID- 38184218
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240314
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 83
DP  - 2024 Apr
TI  - Influence of HLA-A, B, and -DRB1 genes and panel-reactive antibodies on the 
      waitlist time for kidney transplantation in the state of Sao Paulo-Brazil.
PG  - 101981
LID - S0966-3274(23)00198-3 [pii]
LID - 10.1016/j.trim.2023.101981 [doi]
AB  - BACKGROUND: Brazil ranks second in the absolute number of transplants. However, 
      the supply remains insufficient to meet the demands, resulting in a lengthy 
      waitlist. This study aimed to analyze whether the frequency of human leukocyte 
      antigen (HLA) and the value of calculated panel reactive antibody (cPRA) would 
      influence the waiting time for kidney transplantation. METHODS: The HLA-A, B, and 
      -DRB1 frequencies and the cPRA value were analyzed in 11,186 kidney transplant 
      candidates included in the waitlist from 2006 to 2016. RESULTS: The most frequent 
      alleles were HLA-A*02, HLA-B*35, and HLA-DRB1*13. The overall mean length of stay 
      on the list was 986 +/- 1001 days. The mean waiting time for the three most 
      frequent alleles of the HLA-A and B loci showed no significant difference when 
      compared with the least frequent alleles; however, for the HLA-DRB1 locus, the 
      most frequent alleles showed a shorter waiting time. In the association between 
      HLA and PRA, the average length of stay on the list increased according to the 
      candidate's degree of sensitization, regardless of the analyzed HLA frequency. 
      CONCLUSION: The length of stay on the waitlist is influenced by the frequency of 
      the HLA alleles of the DRB1 locus and the degree of sensitization.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Ravazzi-Gauch, Camila
AU  - Ravazzi-Gauch C
AD  - Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School 
      of Sao Jose do Rio Preto-FAMERP, SP, Brazil.
FAU - Marzochi, Ludimila Leite
AU  - Marzochi LL
AD  - Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School 
      of Sao Jose do Rio Preto-FAMERP, SP, Brazil.
FAU - Bajay, Miklos Maximiliano
AU  - Bajay MM
AD  - Department of Genetics, University of Sao Paulo-USP, Piracicaba, SP, Brazil.
FAU - Medeiros, Marizete Peixoto
AU  - Medeiros MP
AD  - Sao Paulo Organ Allocation System, Brazil.
FAU - Caldas, Heloisa Cristina
AU  - Caldas HC
AD  - Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School 
      of Sao Jose do Rio Preto-FAMERP, SP, Brazil.
FAU - Abbud-Filho, Mario
AU  - Abbud-Filho M
AD  - Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School 
      of Sao Jose do Rio Preto-FAMERP, SP, Brazil. Electronic address: 
      mabbud@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA Antigens)
RN  - 0 (Antibodies)
SB  - IM
MH  - Humans
MH  - *Kidney Transplantation
MH  - HLA-DRB1 Chains/genetics
MH  - Brazil
MH  - Waiting Lists
MH  - HLA-A Antigens/genetics
MH  - HLA Antigens
MH  - Alleles
MH  - Antibodies
MH  - Gene Frequency
OTO - NOTNLM
OT  - HLA alleles
OT  - Kidney transplantation
OT  - Panel reactive antibodies
OT  - Waiting list time
COIS- Declaration of competing interest None declared.
EDAT- 2024/01/07 06:44
MHDA- 2024/03/14 06:46
CRDT- 2024/01/06 19:17
PHST- 2023/10/09 00:00 [received]
PHST- 2023/12/19 00:00 [revised]
PHST- 2023/12/31 00:00 [accepted]
PHST- 2024/03/14 06:46 [medline]
PHST- 2024/01/07 06:44 [pubmed]
PHST- 2024/01/06 19:17 [entrez]
AID - S0966-3274(23)00198-3 [pii]
AID - 10.1016/j.trim.2023.101981 [doi]
PST - ppublish
SO  - Transpl Immunol. 2024 Apr;83:101981. doi: 10.1016/j.trim.2023.101981. Epub 2024 
      Jan 4.