PMID- 38184649
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240109
IS  - 2058-7716 (Print)
IS  - 2058-7716 (Electronic)
IS  - 2058-7716 (Linking)
VI  - 10
IP  - 1
DP  - 2024 Jan 6
TI  - Dendritic cell therapy for neurospoagioma: Immunomodulation mediated by tumor 
      vaccine.
PG  - 11
LID - 10.1038/s41420-023-01782-7 [doi]
LID - 11
AB  - Neurospagioma, arising from different glial cells such as astrocytes, 
      oligodendrocytes, and ependymal cells, stands as the prevalent intracranial tumor 
      within the central nervous system. Among its variants, glioblastoma (GBM) 
      represents the most aggressive form, characterized by a notably high occurrence 
      rate and a discouragingly low survival prognosis. The formidable challenge posed 
      by glioblastoma underscores its critical importance as a life-threatening 
      ailment. Currently, clinical approaches often involve surgical excision along 
      with a combination of radiotherapy and chemotherapy. However, these treatments 
      frequently result in a notable recurrence rate, accompanied by substantial 
      adverse effects that significantly compromise the overall prognosis. Hence, there 
      is a crucial need to investigate novel and dependable treatment strategies. 
      Dendritic cells (DCs), being specialized antigen-presenting cells (APCs), hold a 
      significant position in both innate and adaptive immune responses. Presently, DC 
      vaccines have gained widespread application in the treatment of various tumors, 
      including neurospoagioma. In this review, we summarize the immunomodulatory 
      effects and related mechanisms of DC vaccines in neurospoagioma as well as the 
      progress of clinical trials to propose possible challenges of DC vaccines and new 
      development directions.
CI  - (c) 2024. The Author(s).
FAU - Qian, Da
AU  - Qian D
AUID- ORCID: 0000-0002-6062-8161
AD  - Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated 
      to Soochow University, Changshu No.1 People's Hospital, Changshu, 215500, Jiangsu 
      Province, China. drqianda@hotmail.com.
FAU - Liu, Yuxiang
AU  - Liu Y
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical 
      University, 150086, Harbin, China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated 
      to Soochow University, Changshu No.1 People's Hospital, Changshu, 215500, Jiangsu 
      Province, China.
FAU - Cai, Jinquan
AU  - Cai J
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical 
      University, 150086, Harbin, China. caijinquan666777@126.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240106
PL  - United States
TA  - Cell Death Discov
JT  - Cell death discovery
JID - 101665035
PMC - PMC10771477
COIS- The authors declare no competing interests.
EDAT- 2024/01/07 06:44
MHDA- 2024/01/07 06:45
PMCR- 2024/01/06
CRDT- 2024/01/06 23:20
PHST- 2023/08/06 00:00 [received]
PHST- 2023/12/15 00:00 [accepted]
PHST- 2023/12/09 00:00 [revised]
PHST- 2024/01/07 06:45 [medline]
PHST- 2024/01/07 06:44 [pubmed]
PHST- 2024/01/06 23:20 [entrez]
PHST- 2024/01/06 00:00 [pmc-release]
AID - 10.1038/s41420-023-01782-7 [pii]
AID - 1782 [pii]
AID - 10.1038/s41420-023-01782-7 [doi]
PST - epublish
SO  - Cell Death Discov. 2024 Jan 6;10(1):11. doi: 10.1038/s41420-023-01782-7.