PMID- 38184892 OWN - NLM STAT- MEDLINE DCOM- 20240214 LR - 20240321 IS - 1872-8421 (Electronic) IS - 0165-5728 (Linking) VI - 387 DP - 2024 Feb 15 TI - Inherited chromosomally-integrated human herpes virus 6 confounding test results in a patient with myelitis and optic neuritis - A case report. PG - 578283 LID - S0165-5728(24)00001-8 [pii] LID - 10.1016/j.jneuroim.2024.578283 [doi] AB - A case of the 'perfect storm' of myelin oligodendrocyte glycoprotein (MOG) antibody-mediated myelitis, human herpesvirus 6 (HHV-6) reactivation, and COVID-19 infection was reported in 2021. This article reports a case of a similarly observed clinical triad, but with a different conclusion and explanation supported by laboratory test results and evidence from our literature review. CI - Copyright (c) 2024 Elsevier B.V. All rights reserved. FAU - Tan, Zhibin AU - Tan Z AD - Department of Neurology, National Neuroscience Institute, Singapore; Neuroscience Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre, Singapore. Electronic address: tan.zhibin@singhealth.com.sg. FAU - Chia, Yvonne May Fen AU - Chia YMF AD - Department of Infectious Diseases, Singapore General Hospital, Singapore. FAU - Mu, Xiaomin AU - Mu X AD - Department of Neurology, National Neuroscience Institute, Singapore. FAU - Tan, You-Jiang AU - Tan YJ AD - Department of Neurology, National Neuroscience Institute, Singapore; Neuroscience Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre, Singapore. LA - eng PT - Case Reports PT - Journal Article PT - Review DEP - 20240104 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - 0 (Autoantibodies) RN - 0 (Myelin-Oligodendrocyte Glycoprotein) SB - IM MH - Humans MH - *Herpesvirus 6, Human/genetics MH - Autoantibodies MH - Myelin-Oligodendrocyte Glycoprotein MH - *Myelitis MH - *Optic Neuritis OTO - NOTNLM OT - COVID-19 OT - Chromosomally integrated OT - HHV6 OT - Human herpes virus 6 OT - Inherited OT - MOG OT - MOGAD OT - Myelin oligodendrocyte glycoprotein COIS- Declaration of competing interest On behalf of all authors, the corresponding author states that there is no conflict of interest. EDAT- 2024/01/08 00:42 MHDA- 2024/02/11 07:43 CRDT- 2024/01/07 18:05 PHST- 2023/12/17 00:00 [received] PHST- 2023/12/25 00:00 [revised] PHST- 2023/12/31 00:00 [accepted] PHST- 2024/02/11 07:43 [medline] PHST- 2024/01/08 00:42 [pubmed] PHST- 2024/01/07 18:05 [entrez] AID - S0165-5728(24)00001-8 [pii] AID - 10.1016/j.jneuroim.2024.578283 [doi] PST - ppublish SO - J Neuroimmunol. 2024 Feb 15;387:578283. doi: 10.1016/j.jneuroim.2024.578283. Epub 2024 Jan 4.