PMID- 38185814 OWN - NLM STAT- MEDLINE DCOM- 20240320 LR - 20240320 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 131 IP - 8 DP - 2024 Apr 28 TI - Inverse association between maternal serum concentrations of trace elements and risk of spontaneous preterm birth: a nested case-control study in China. PG - 1425-1435 LID - 10.1017/S0007114523003070 [doi] AB - Few studies have evaluated the joint effect of trace elements on spontaneous preterm birth (SPTB). This study aimed to examine the relationships between the individual or mixed maternal serum concentrations of Fe, Cu, Zn, Se, Sr and Mo during pregnancy, and risk of SPTB. Inductively coupled plasma MS was employed to determine maternal serum concentrations of the six trace elements in 192 cases with SPTB and 282 controls with full-term delivery. Multivariate logistic regression, weighted quantile sum regression (WQSR) and Bayesian kernel machine regression (BKMR) were used to evaluate the individual and joint effects of trace elements on SPTB. The median concentrations of Sr and Mo were significantly higher in controls than in SPTB group (P < 0.05). In multivariate logistic regression analysis, compared with the lowest quartile levels of individual trace elements, the third- and fourth-quartile Sr or Mo concentrations were significantly associated with reduced risk of SPTB with adjusted OR (aOR) of 0.432 (95 CI < 0.05). In multivariate logistic regression analysis, compared with the lowest quartile levels of individual trace elements, the third- and fourth-quartile Sr or Mo concentrations were significantly associated with reduced risk of SPTB with adjusted aOR of 0.432 (95 % CI 0.247, 0.756), 0.386 (95 % CI 0.213, 0.701), 0.512 (95 % CI 0.297, 0.883) and 0.559 (95 % CI 0.321, 0.972), respectively. WQSR revealed the inverse combined effect of the trace elements mixture on SPTB (aOR = 0.368, 95 % CI 0.228, 0.593). BKMR analysis confirmed the overall mixture of the trace elements was inversely associated with the risk of SPTB, and the independent effect of Sr and Mo was significant. Our findings suggest that the risk of SPTB decreased with concentrations of the six trace elements, with Sr and Mo being the major contributors. FAU - Li, Nana AU - Li N AUID- ORCID: 0000-0001-9849-5299 AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Yu, Ping AU - Yu P AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Liu, Zhen AU - Liu Z AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Tao, Jing AU - Tao J AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Li, Lu AU - Li L AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Wang, Meixian AU - Wang M AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Wei, Hongwei AU - Wei H AD - Maternal and Child Healthcare Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China. FAU - Zhu, Yibing AU - Zhu Y AD - Fujian Provincial Maternal and Child Healthcare Hospital, Fuzhou, Fujian, People's Republic of China. FAU - Deng, Ying AU - Deng Y AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Kang, Hong AU - Kang H AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Li, Yuting AU - Li Y AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Li, Xiaohong AU - Li X AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Liang, Juan AU - Liang J AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Wang, Yanping AU - Wang Y AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. FAU - Zhu, Jun AU - Zhu J AD - National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, Sichuan, People's Republic of China. LA - eng PT - Journal Article DEP - 20240108 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 RN - 0 (Trace Elements) SB - IM MH - Pregnancy MH - Female MH - Infant, Newborn MH - Humans MH - *Trace Elements MH - *Premature Birth MH - Case-Control Studies MH - Bayes Theorem MH - China/epidemiology OTO - NOTNLM OT - Bayesian kernel machine regression OT - Joint effect OT - Spontaneous preterm birth OT - Trace elements OT - Weighted quantile sum regression EDAT- 2024/01/08 00:42 MHDA- 2024/03/20 06:46 CRDT- 2024/01/07 23:53 PHST- 2024/03/20 06:46 [medline] PHST- 2024/01/08 00:42 [pubmed] PHST- 2024/01/07 23:53 [entrez] AID - S0007114523003070 [pii] AID - 10.1017/S0007114523003070 [doi] PST - ppublish SO - Br J Nutr. 2024 Apr 28;131(8):1425-1435. doi: 10.1017/S0007114523003070. Epub 2024 Jan 8.