PMID- 38186523
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240109
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 12
DP  - 2023 Dec
TI  - Metastatic Epithelioid Pleomorphic Liposarcoma in the Brain: A Case Report.
PG  - e50066
LID - 10.7759/cureus.50066 [doi]
LID - e50066
AB  - Metastatic soft tissue sarcoma (STS) to the brain is rare, and metastatic 
      pleomorphic liposarcoma (PLPS) to the brain is even rarer. We present the case of 
      a 76-year-old male with an incidental finding of a brain mass on a brain magnetic 
      resonance imaging (MRI) following a head injury. Additionally, multiple pulmonary 
      nodules and a right gluteal mass were discovered. A core biopsy of the right 
      gluteal mass revealed an epithelioid malignant neoplasm expressing transcription 
      factor enhancer 3 (TFE3) by immunohistochemistry (IHC). Subsequently, the left 
      middle fossa brain mass was removed and found to be an epithelioid PLPS, which 
      was positive for TFE3 by IHC but lacked TFE3 rearrangement by fluorescence in 
      situ hybridization (FISH), and negative for murine double minute (MDM2) 
      amplification by FISH. The diagnosis of epithelioid PLPS mainly relies on 
      histomorphology. This paper discusses the clinicopathological correlation of 
      PLPS, including the epithelioid variant, with a focus on cases with brain 
      metastases.
CI  - Copyright (c) 2023, Wang et al.
FAU - Wang, Tengfei
AU  - Wang T
AD  - Pathology, Baylor Scott & White Health, Temple, USA.
FAU - Waworuntu, Kiersten L
AU  - Waworuntu KL
AD  - Pathology, Baylor Scott & White Health, Temple, USA.
FAU - Shan, Frank Y
AU  - Shan FY
AD  - Pathology and Neurosurgery, Baylor Scott & White Health, Temple, USA.
LA  - eng
PT  - Case Reports
DEP - 20231206
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10769534
OTO - NOTNLM
OT  - brain metastasis
OT  - epithelioid variant
OT  - histomorphology
OT  - mdm2
OT  - pleomorphic liposarcoma
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/01/08 06:43
MHDA- 2024/01/08 06:44
PMCR- 2023/12/06
CRDT- 2024/01/08 04:26
PHST- 2023/10/26 00:00 [received]
PHST- 2023/12/05 00:00 [accepted]
PHST- 2024/01/08 06:44 [medline]
PHST- 2024/01/08 06:43 [pubmed]
PHST- 2024/01/08 04:26 [entrez]
PHST- 2023/12/06 00:00 [pmc-release]
AID - 10.7759/cureus.50066 [doi]
PST - epublish
SO  - Cureus. 2023 Dec 6;15(12):e50066. doi: 10.7759/cureus.50066. eCollection 2023 
      Dec.