PMID- 38186880
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240109
IS  - 2048-8505 (Print)
IS  - 2048-8513 (Electronic)
IS  - 2048-8505 (Linking)
VI  - 17
IP  - 1
DP  - 2024 Jan
TI  - Age- and time-dependent increases in incident anti-glomerular basement membrane 
      disease: a nationwide cohort study.
PG  - sfad261
LID - 10.1093/ckj/sfad261 [doi]
LID - sfad261
AB  - BACKGROUND: Epidemiologic assessments of anti-glomerular basement membrane (GBM) 
      disease have been challenging due to its rare occurrence. We examined changes in 
      the incidence and outcomes from 1998 to 2018 using nationwide healthcare 
      registries. METHODS: All patients with incident anti-GBM disease were identified 
      using the International Classification of Diseases, 10th Revision code DM31.0A. 
      Controls were matched 4:1 on birthyear and sex using exposure density sampling. 
      Log link regression adjusted for time, age and sex was applied to model survival. 
      RESULTS: We identified 97 patients with incident anti-GBM disease, corresponding 
      to an incidence of 0.91 cases/million/year [standard deviation (SD) 0.6]. The 
      incidence increased over time [1998-2004: 0.50 (SD 0.2), 2005-2011: 0.80 (SD 
      0.4), 2012-2018: 1.4 (SD 0.5); P = .02] and with age [0.76 (SD 0.4), 1.5 (SD 
      1.04) and 4.9 (SD 2.6) for patients <45, 45-75 and >75 years]. The median age was 
      56 years (interquartile range 46) and 51.6% were female. Dialysis was required in 
      58.4%, 61.9% and 62.9% of patients at day 30, 180 and 360, respectively. The 
      1-year kidney survival probability was 0.38 (SD 0.05) and exhibited 
      time-dependent changes [1998-2004: 0.47 (SD 0.13), 2005-2011: 0.16 (SD 0.07), 
      2012-2018: 0.46 (SD 0.07); P = .035]. The 5-year mortality was 26.8% and 
      mortality remained stable over time (P = .228). The risk of death was greater 
      than that of the matched background population absolute risk ratio [ARR] 5.27 
      [confidence interval (CI) 2.45-11.3], P < .001, however, it was comparable to 
      that of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis 
      (AAV) requiring renal dialysis at presentation [ARR 0.82 (CI 0.48-1.41), 
      P = .50]. CONCLUSION: The incidence of anti-GBM disease increased over time, 
      possibly related to temporal demographic changes. Mortality remained high and was 
      comparable with an age- and sex-matched cohort of dialysis-dependent AAV 
      patients.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.
FAU - Nelveg-Kristensen, Karl Emil
AU  - Nelveg-Kristensen KE
AD  - Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Madsen, Bo
AU  - Madsen B
AD  - Department of Nephrology, SLE and Vasculitis Clinic, Aalborg University Hospital, 
      Aalborg, Denmark.
FAU - McClure, Mark
AU  - McClure M
AUID- ORCID: 0000-0002-0398-9817
AD  - Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge University 
      Hospitals, Cambridge, UK.
FAU - Bruun, Nanna
AU  - Bruun N
AD  - Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Lyngso, Cecilie
AU  - Lyngso C
AD  - Department of Nephrology, Zealand University Hospital, Roskilde, Denmark.
FAU - Dieperink, Hans
AU  - Dieperink H
AD  - Department of Nephrology, Odense University Hospital, Odense, Denmark.
FAU - Gregersen, Jon Waarst
AU  - Gregersen JW
AD  - Department of Nephrology, SLE and Vasculitis Clinic, Aalborg University Hospital, 
      Aalborg, Denmark.
FAU - Krarup, Elizabeth
AU  - Krarup E
AD  - Department of Nephrology, Herlev Hospital, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Ivarsen, Per
AU  - Ivarsen P
AD  - Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark.
AD  - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
FAU - Torp-Pedersen, Christian
AU  - Torp-Pedersen C
AD  - Department of Cardiology, Nordsjaellands Hospital, Hillerod, Denmark.
AD  - Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
FAU - Egfjord, Martin
AU  - Egfjord M
AD  - Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Szpirt, Wladimir
AU  - Szpirt W
AD  - Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Carlson, Nicholas
AU  - Carlson N
AD  - Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, 
      Copenhagen, Denmark.
CN  - Danish Vasculitis Association (DANVAS)
LA  - eng
PT  - Journal Article
DEP - 20231016
PL  - England
TA  - Clin Kidney J
JT  - Clinical kidney journal
JID - 101579321
PMC - PMC10768786
OTO - NOTNLM
OT  - age
OT  - analysis
OT  - epidemiology
OT  - gender
OT  - prognosis
OT  - survival
COIS- None of the authors have any conflicts of interests.
EDAT- 2024/01/08 06:43
MHDA- 2024/01/08 06:44
PMCR- 2023/10/16
CRDT- 2024/01/08 04:32
PHST- 2023/04/20 00:00 [received]
PHST- 2024/01/08 06:44 [medline]
PHST- 2024/01/08 06:43 [pubmed]
PHST- 2024/01/08 04:32 [entrez]
PHST- 2023/10/16 00:00 [pmc-release]
AID - sfad261 [pii]
AID - 10.1093/ckj/sfad261 [doi]
PST - epublish
SO  - Clin Kidney J. 2023 Oct 16;17(1):sfad261. doi: 10.1093/ckj/sfad261. eCollection 
      2024 Jan.