PMID- 38186982
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240109
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 15
IP  - 12
DP  - 2023
TI  - Aspirin inhibits the biological behavior of gallbladder carcinoma cells by 
      modulating vascular endothelial growth factor.
PG  - 6779-6785
AB  - OBJECTIVE: To elucidate the effect of aspirin (ASP) on the biological behavior of 
      gallbladder carcinoma (GBC) cells and its influence on vascular endothelial 
      growth factor (VEGF) expression. METHODS: Cell Counting Kit-8 (CCK-8) assay was 
      performed to determine the effects of ASP on GBC-SD cell proliferation. In 
      addition, Transwell assay and flow cytometry were carried out to observe the role 
      of ASP in GBC-SD cell migration, invasion and apoptosis, respectively. Tumor 
      necrosis factor-alpha (TNF-alpha), nuclear factor kappa-B (NF-kappaB), and VEGF 
      concentrations in GBC-SD cells were examined by enzyme-linked immunosorbent 
      assays (ELISAs). RESULTS: ASP suppressed GBC-SD cell proliferation in a 
      dose-dependent manner, and a concentration >/= 2 mmol/L could significantly inhibit 
      the migration and invasion of GBC-SD cells and induce apoptosis. In addition, the 
      anticancer effect of ASP in GBC-SD cells may be linked to its inhibition of 
      TNF-alpha, NF-kappaB, and VEGF levels. CONCLUSIONS: ASP may markedly inhibit GBC-SD cell 
      growth by significantly reducing TNF-alpha, NF-kappaB and VEGF expression.
CI  - AJTR Copyright (c) 2023.
FAU - Zhu, Mingyuan
AU  - Zhu M
AD  - Department of General Surgery, The Second Affiliated Hospital of Jiaxing 
      University Jiaxing 314000, Zhejiang, China.
FAU - Huang, Yanhua
AU  - Huang Y
AD  - Department of General Surgery, The Second Affiliated Hospital of Jiaxing 
      University Jiaxing 314000, Zhejiang, China.
FAU - Zhou, Zhongcheng
AU  - Zhou Z
AD  - Department of General Surgery, The Second Affiliated Hospital of Jiaxing 
      University Jiaxing 314000, Zhejiang, China.
FAU - Liu, Xiaolin
AU  - Liu X
AD  - Department of General Surgery, The Second Affiliated Hospital of Jiaxing 
      University Jiaxing 314000, Zhejiang, China.
FAU - Zhou, Chunhui
AU  - Zhou C
AD  - Department of General Surgery, The Second Affiliated Hospital of Jiaxing 
      University Jiaxing 314000, Zhejiang, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of General Surgery, The Second Affiliated Hospital of Jiaxing 
      University Jiaxing 314000, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20231215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC10767515
OTO - NOTNLM
OT  - Aspirin
OT  - VEGF
OT  - cell biology
OT  - gallbladder carcinoma
COIS- None.
EDAT- 2024/01/08 06:42
MHDA- 2024/01/08 06:43
PMCR- 2023/12/15
CRDT- 2024/01/08 04:33
PHST- 2023/10/09 00:00 [received]
PHST- 2023/11/30 00:00 [accepted]
PHST- 2024/01/08 06:43 [medline]
PHST- 2024/01/08 06:42 [pubmed]
PHST- 2024/01/08 04:33 [entrez]
PHST- 2023/12/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2023 Dec 15;15(12):6779-6785. eCollection 2023.