PMID- 38187278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240109
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 1
DP  - 2024 Jan 15
TI  - The timing of death in acute pulmonary embolism patients regarding the mortality 
      risk stratification at admission to the hospital.
PG  - e23536
LID - 10.1016/j.heliyon.2023.e23536 [doi]
LID - e23536
AB  - BACKGROUND: The management of patients with acute pulmonary embolism (aPE) 
      depends on the severity of aPE. The timing of death in various aPE risk subgroups 
      is only partially known. METHODS: 1618 patients with an objectively established 
      aPE diagnosis with computed tomography pulmonary angiography enrolled in the 
      regional PE registry were included in the study. According to ESC criteria, 
      patients were stratified at admission to the hospital in four risk strata. The 
      timing of PE-related and non-PE-related deaths was analyzed regarding mortality 
      risk. RESULTS: PE-related, and non-PE-related hospital death rates were 1.1 % and 
      1.5 % in low, 1.1 % and 4.8 % in intermediate-low, 8.1 % and 5.9 % in 
      intermediate-high, and 27.7 % and 6.9 % in high-risk groups, respectively. The 
      median time of PE-related and non-PE-related death across the PE mortality risk 
      were: 4 (1.7-7.5) and 7.0 (4-14.7) days in low, 1.5 (1.0-9.5) and 11.5 (2.0-21.0) 
      days in intermediate-low, 4.0 (2.0-9.0) and 9.0 (5.7-18.2) days in 
      intermediate-high, 2.0 (1.0-4.75) and 7.0 (3.0-21.2) days in high-risk subgroups. 
      48.2 % and 17.1 % of patients who died in the high and intermediate-high risks 
      died during the first hospital day. After the 6th hospitalization day, PE-related 
      deaths were recorded in 43.9 % of deaths from intermediate-high and 17.9 % from 
      high-risk subgroups. CONCLUSION: PE-related mortality is prominent on the first 
      hospitalization day in high and intermediate-high-risk PE. A substantial 
      proportion of intermediate-high and high-risk patient's PE deaths occurred after 
      the first 6 days of hospitalization.
CI  - (c) 2023 The Authors.
FAU - Obradovic, Slobodan
AU  - Obradovic S
AD  - Clinic of Cardiology, Military Medical Academy of Belgrade, Serbia.
AD  - School of Medicine, University of Defense, Belgrade, Serbia.
FAU - Dzudovic, Boris
AU  - Dzudovic B
AD  - School of Medicine, University of Defense, Belgrade, Serbia.
AD  - Clinic of Emergency Internal Medicine, Military Medical Academy, Belgrade, 
      Serbia.
FAU - Pruszczyk, Piotr
AU  - Pruszczyk P
AD  - Department of Internal Medicine and Cardiology, Medical University of Warsaw, 
      Poland.
FAU - Djuric, Ivica
AU  - Djuric I
AD  - Clinic of Cardiology, Military Medical Academy of Belgrade, Serbia.
FAU - Subotic, Bojana
AU  - Subotic B
AD  - Clinic of Cardiology, Military Medical Academy of Belgrade, Serbia.
FAU - Matijasevic, Jovan
AU  - Matijasevic J
AD  - Institute of Pulmonary Diseases Vojvodina, Novi Sad, Serbia.
AD  - School of Medicine, University of Novi Sad, Serbia.
FAU - Benic, Marija
AU  - Benic M
AD  - Institute of Pulmonary Diseases Vojvodina, Novi Sad, Serbia.
FAU - Salinger, Sonja
AU  - Salinger S
AD  - Clinic of Cardiology, Clinical Center Nis, Serbia.
AD  - School of Medicine, University of Nis, Serbia.
FAU - Kos, Ljiljana
AU  - Kos L
AD  - Clinic of Cardiology, Clinical Center Banja Luka, Bosnia and Herzegovina.
FAU - Kovacevic-Preradovic, Tamara
AU  - Kovacevic-Preradovic T
AD  - Clinic of Cardiology, Clinical Center Banja Luka, Bosnia and Herzegovina.
AD  - School of Medicine, University of Banja Luka, Bosnia and Herzegovina.
FAU - Mitevska, Irena
AU  - Mitevska I
AD  - University Cardiology Clinic, Intensive Care Unit, Skopje, Macedonia.
FAU - Kafedzic, Srdjan
AU  - Kafedzic S
AD  - Clinic of Cardiology, University Clinical Center Zemun, Serbia.
FAU - Neskovic, Aleksandar
AU  - Neskovic A
AD  - Clinic of Cardiology, University Clinical Center Zemun, Serbia.
AD  - School of Medicine, University of Belgrade, Serbia.
FAU - Bozovic, Bjanka
AU  - Bozovic B
AD  - Clinic of Cardiology, Clinical Center Podgorica, Montenegro.
AD  - School of Medicine, University of Podgorica, Montenegro.
FAU - Bulatovic, Nebojsa
AU  - Bulatovic N
AD  - Clinic of Cardiology, Clinical Center Podgorica, Montenegro.
AD  - School of Medicine, University of Podgorica, Montenegro.
FAU - Miloradovic, Vladimir
AU  - Miloradovic V
AD  - Clinic of Cardiology, Clinical Center Kragujevac, Serbia.
AD  - School of Medicine, University of Kragujevac, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20231212
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10767379
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/01/08 06:42
MHDA- 2024/01/08 06:43
PMCR- 2023/12/12
CRDT- 2024/01/08 04:38
PHST- 2023/04/22 00:00 [received]
PHST- 2023/12/05 00:00 [revised]
PHST- 2023/12/06 00:00 [accepted]
PHST- 2024/01/08 06:43 [medline]
PHST- 2024/01/08 06:42 [pubmed]
PHST- 2024/01/08 04:38 [entrez]
PHST- 2023/12/12 00:00 [pmc-release]
AID - S2405-8440(23)10744-4 [pii]
AID - e23536 [pii]
AID - 10.1016/j.heliyon.2023.e23536 [doi]
PST - epublish
SO  - Heliyon. 2023 Dec 12;10(1):e23536. doi: 10.1016/j.heliyon.2023.e23536. 
      eCollection 2024 Jan 15.