PMID- 38189852 OWN - NLM STAT- MEDLINE DCOM- 20240304 LR - 20240304 IS - 1433-3023 (Electronic) IS - 0937-3462 (Linking) VI - 35 IP - 2 DP - 2024 Feb TI - Correlation Between Insulin Resistance and Urinary Incontinence in Female Patients with Type 2 Diabetes Mellitus. PG - 431-440 LID - 10.1007/s00192-023-05715-x [doi] AB - INTRODUCTION AND HYPOTHESIS: Patients with type 2 diabetes mellitus (T2DM) are at a high risk of developing urinary incontinence; however, its pathogenesis is unclear. The purpose of this study is to explore the relationship between insulin resistance and urinary incontinence and its severity in female patients with T2DM. METHODS: A total of 366 women with T2DM aged >/=18 years were enrolled in this study. Insulin resistance was evaluated by the homeostasis model insulin resistance (HOMA-IR) index and urinary incontinence was assessed by the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF). All subjects were divided into four groups according to HOMA-IR quartiles. Logistic regression analysis was performed to investigate the relationship between insulin resistance and urinary incontinence and its severity. RESULTS: Among the 366 patients, 186 (50.8%) had urinary incontinence. The prevalence of urinary incontinence increased significantly with HOMA-IR quartiles (p < 0.001). Adjusted logistic regression analysis showed that compared with HOMA-IR /= 4.28 was associated with a significantly increased risk of severe incontinence (OR = 5.699, 95% CI 1.685-19.276, p = 0.005). Binary logistic regression analysis showed that HOMA-IR was the independent risk factor for urinary incontinence (p < 0.001). CONCLUSIONS: Higher levels of insulin resistance are associated with urinary incontinence and its severity in female patients with type 2 diabetes mellitus. CI - (c) 2024. The International Urogynecological Association. FAU - Li, Shuyun AU - Li S AD - The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China. FAU - Zou, Jingyi AU - Zou J AD - The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China. FAU - Wang, Zhen AU - Wang Z AD - The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China. FAU - Wang, Mengke AU - Wang M AD - The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China. FAU - Yuan, Yue AU - Yuan Y AD - The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China. FAU - Lv, Haihong AU - Lv H AD - Department of Endocrinology, The First Hospital of Lanzhou University, 1 Donggang West Road, Lanzhou, 730000, Gansu, China. lvhh@lzu.edu.cn. LA - eng PT - Journal Article DEP - 20240108 PL - England TA - Int Urogynecol J JT - International urogynecology journal JID - 101567041 RN - 0 (Insulin) SB - IM MH - Humans MH - Female MH - Adolescent MH - Adult MH - *Insulin Resistance MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Cross-Sectional Studies MH - *Urinary Incontinence/epidemiology/etiology MH - Insulin OTO - NOTNLM OT - ICIQ-SF OT - Insulin resistance OT - Type 2 diabetes mellitus OT - Urinary incontinence EDAT- 2024/01/08 12:42 MHDA- 2024/03/04 06:48 CRDT- 2024/01/08 11:05 PHST- 2023/09/06 00:00 [received] PHST- 2023/12/06 00:00 [accepted] PHST- 2024/03/04 06:48 [medline] PHST- 2024/01/08 12:42 [pubmed] PHST- 2024/01/08 11:05 [entrez] AID - 10.1007/s00192-023-05715-x [pii] AID - 10.1007/s00192-023-05715-x [doi] PST - ppublish SO - Int Urogynecol J. 2024 Feb;35(2):431-440. doi: 10.1007/s00192-023-05715-x. Epub 2024 Jan 8.