PMID- 38191140
OWN - NLM
STAT- MEDLINE
DCOM- 20240110
LR  - 20240110
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 76
IP  - 1
DP  - 2024 Jan
TI  - [Clinical Features and Pathogenesis of Double Seronegative Myasthenia Gravis].
PG  - 55-60
LID - 10.11477/mf.1416202558 [doi]
AB  - Subjects with double seronegative myasthenia gravis (DNMG) are defined as those 
      who are seronegative to both antibodies against acetylcholine receptor (AChR) and 
      muscle-specific kinase (MuSK) by radioimmunoprecipitation assay (RIA). They are 
      basically heterogeneous. But cell based assay (CBA) with clustered AChR has 
      revealed a considerable part of DNMG are AChR antibody associated. Furthermore, 
      information of clinical features and thymus pathology has raised a possibility 
      that this could extend to those with undetectable antibodies by established 
      assays whose symptoms are mild. Primary sites of antibody production are probably 
      in the thymus in these cases. LOMG pathology is also suspected for a small part 
      of DNMG by age onset, atrophic or age-related thymus and presence of titin 
      antibody. In these cases, tolerance induction may be insufficient, and positive 
      selection of autoimmune T cells such as AChR-specific T cells are promoted rather 
      than negative selection. In addition, CBA detected MuSK antibody associated in a 
      few cases with DNMG. Finally, some DNMG subjects have distinct clinical features 
      with severe symptoms from those with AChR- MG and MuSK-MG in DNMG. They probably 
      have different pathogenesis.
FAU - Kondo, Takayuki
AU  - Kondo T
AD  - Department of Neurology, Kansai Medical University Medical Center.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Humans
MH  - *Myasthenia Gravis/diagnosis
MH  - Atrophy
MH  - Autoantibodies
EDAT- 2024/01/09 00:42
MHDA- 2024/01/10 06:41
CRDT- 2024/01/08 19:53
PHST- 2024/01/10 06:41 [medline]
PHST- 2024/01/09 00:42 [pubmed]
PHST- 2024/01/08 19:53 [entrez]
AID - 1416202558 [pii]
AID - 10.11477/mf.1416202558 [doi]
PST - ppublish
SO  - Brain Nerve. 2024 Jan;76(1):55-60. doi: 10.11477/mf.1416202558.