PMID- 38191275
OWN - NLM
STAT- Publisher
LR  - 20240108
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
DP  - 2024 Jan 8
TI  - Positive correlation of ANGPTL8 expression in human visceral adipose tissue with 
      body mass index.
LID - S0929-6646(23)00498-9 [pii]
LID - 10.1016/j.jfma.2023.12.018 [doi]
AB  - BACKGROUND: Angiopoietin-like protein 8 (ANGPTL8) is an important regulator of 
      lipid metabolism. We aimed to investigate the difference of ANGPTL8 expression in 
      different depots of adipose tissues between individuals with and without obesity, 
      and its correlation with various metabolic parameters. METHODS: Subcutaneous 
      (SAT) and visceral adipose tissue (VAT) samples were collected from patients who 
      underwent bariatric or intra-abdominal surgery. Expression levels of ANGPTL8, 
      monoglyceride lipase (MGL), monocyte chemoattractant protein-1 (MCP-1), leptin 
      and adiponectin (APM1) were determined using real-time quantitative polymerase 
      chain reaction. The correlation of ANGPTL8 expression with various metabolic 
      parameters and other gene expression levels was analyzed using Person's 
      correlation analysis. Logistic regression was used to establish a prediction 
      model of obesity. RESULTS: Totally 330 subjects (obese: 281, non-obese: 49) were 
      recruited. ANGPTL8 expression in VAT was significantly higher in the obesity 
      group than in the non-obesity group (P = 0.0096). ANGPTL8 expression in VAT was 
      positively correlated with body mass index (BMI) (r = 0.1169, P < 0.05) and was 
      independently associated with obesity (O.R., 1.246; 95 % C.I. 1.013-21.533, 
      P = 0.038). We also found the gene expression of ANGPTL8 in SAT and VAT was 
      negatively correlated with APM1 expression in respective SAT and VAT. 
      CONCLUSIONS: ANGPTL8 expression levels in VAT were higher in subjects with 
      obesity, and positively correlated with BMI. This suggests a role of ANGPTL8 in 
      the pathophysiology of obesity and may pave the way for novel treatment target of 
      obesity.
CI  - Copyright (c) 2023 Formosan Medical Association. Published by Elsevier B.V. All 
      rights reserved.
FAU - Chen, Shiau-Mei
AU  - Chen SM
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Huang, Tse-Ying
AU  - Huang TY
AD  - Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu 
      Branch, Taiwan.
FAU - Lee, Wei-Jei
AU  - Lee WJ
AD  - Department of Surgery, Taoyuan Min-Sheng General Hospital, Taoyuan, Taiwan.
FAU - Chuang, Lee-Ming
AU  - Chuang LM
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan; School of Medicine, National Taiwan University, Taipei, Taiwan; Graduate 
      Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan; 
      Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, 
      College of Public Health, National Taiwan University, Taipei, Taiwan.
FAU - Chang, Tien-Jyun
AU  - Chang TJ
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan; School of Medicine, National Taiwan University, Taipei, Taiwan. 
      Electronic address: tjc922@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240108
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
SB  - IM
OTO - NOTNLM
OT  - ANGPTL8
OT  - Bariatric surgery
OT  - Body mass index
OT  - Obesity
OT  - Visceral fat
COIS- Declaration of competing interest The authors declare that they have no conflicts 
      of interest.
EDAT- 2024/01/09 00:42
MHDA- 2024/01/09 00:42
CRDT- 2024/01/08 21:51
PHST- 2023/05/13 00:00 [received]
PHST- 2023/12/21 00:00 [revised]
PHST- 2023/12/27 00:00 [accepted]
PHST- 2024/01/09 00:42 [medline]
PHST- 2024/01/09 00:42 [pubmed]
PHST- 2024/01/08 21:51 [entrez]
AID - S0929-6646(23)00498-9 [pii]
AID - 10.1016/j.jfma.2023.12.018 [doi]
PST - aheadofprint
SO  - J Formos Med Assoc. 2024 Jan 8:S0929-6646(23)00498-9. doi: 
      10.1016/j.jfma.2023.12.018.