PMID- 38191455
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240111
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Jan 9
TI  - The association between plasma free amino acids and type 2 diabetes mellitus 
      complicated with infection in Chinese patients.
PG  - 9
LID - 10.1186/s13098-023-01203-w [doi]
LID - 9
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM), one of the most common public 
      diseases threatening human health, is always accompanied by infection. Though 
      there are still a variety of flaws in the treatment of some infectious diseases, 
      metabolomics provides a fresh perspective to explore the relationship between 
      T2DM and infection. Our research aimed to investigate the association between 
      plasma free amino acids (PFAAs) and T2DM complicated with infection in Chinese 
      patients. METHODS: A cross-sectional study was conducted from May 2015 to August 
      2016. We retrieved the medical records of 1032 inpatients with T2DM from Liaoning 
      Medical University First Affiliated Hospital and we used mass spectrometry to 
      quantify 23 PFAAs. Infections contained 15 individual categories that could be 
      retrieved from the database. Principal component analysis was used to extract 
      factors of PFAAs. Multi-variable binary logistic regression was used to obtain 
      odds ratios (OR) and their 95% confidence intervals (CI). RESULTS: Among 1032 
      inpatients,109 (10.6%) had infectious diseases. Six factors, accounting for 68.6% 
      of the total variance, were extracted. Factor 4 consisted of Glu, Asp and Orn. 
      Factor 5 consisted of Hcy and Pip. After adjusting for potential confounders, 
      factor 4 was positively correlated with T2DM complicated with infection in 
      Chinese T2DM patients (OR: 1.27, 95%CI: 1.06-1.52). Individual Hcy in factor 5 
      was positively associated with T2DM complicated with infection (OR: 1.33, 95%CI: 
      1.08-1.64). Furthermore, factor 4 (OR: 1.44, 95%CI: 1.11-1.87), Orn (OR: 1.01, 
      95%CI: 1.00-1.02) and Hcy (OR: 1.56, 95%CI: 1.14-3.14) were positively associated 
      with bacterial infection in Chinese T2DM patients, while factor 5 (OR: 0.71, 
      95%CI: 0.50-1.00) was negatively associated with bacterial infection. 
      CONCLUSIONS: Urea cycle-related metabolites (Orn, Asp, Glu) and Hcy were 
      positively associated with T2DM complicated with infection in China. Orn and Hcy 
      were positively associated with bacterial infection in T2DM patients in China.
CI  - (c) 2024. The Author(s).
FAU - Zhang, Jing-Xi
AU  - Zhang JX
AD  - Department of Pediatric Dentistry, School and Hospital of Stomatology, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China.
FAU - Luo, Wei-Ming
AU  - Luo WM
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China.
FAU - Wang, Bo-Wen
AU  - Wang BW
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China.
FAU - Li, Ru-Tao
AU  - Li RT
AD  - Department of Pediatric Dentistry, School and Hospital of Stomatology, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China.
FAU - Zhang, Xiang-Yu
AU  - Zhang XY
AD  - Department of Pediatric Dentistry, School and Hospital of Stomatology, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China. xzhang04@tmu.edu.cn.
FAU - Fang, Zhong-Ze
AU  - Fang ZZ
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, No.22, Xinxing Street, Heping District, Tianjin, 300041, 
      China. fangzhongze@tmu.edu.cn.
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      300041, China. fangzhongze@tmu.edu.cn.
FAU - Zhang, Zhi-Peng
AU  - Zhang ZP
AD  - General Surgery of Peking University Third Hospital, Beijing, China.
LA  - eng
GR  - 2021YFA1301202/National Key Research and Development Program of China/
GR  - 82273676/National Natural Science Foundation of China/
GR  - 2021JH2/10300039/Liaoning Province Scientific and Technological Project/
PT  - Journal Article
DEP - 20240109
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC10775586
OTO - NOTNLM
OT  - Chinese
OT  - Infection
OT  - Metabolism
OT  - Plasma free amino acid
OT  - Type 2 Diabetes Mellitus
COIS- The authors declare no competing interests.
EDAT- 2024/01/09 00:42
MHDA- 2024/01/09 00:43
PMCR- 2024/01/09
CRDT- 2024/01/08 23:41
PHST- 2023/05/13 00:00 [received]
PHST- 2023/11/01 00:00 [accepted]
PHST- 2024/01/09 00:43 [medline]
PHST- 2024/01/09 00:42 [pubmed]
PHST- 2024/01/08 23:41 [entrez]
PHST- 2024/01/09 00:00 [pmc-release]
AID - 10.1186/s13098-023-01203-w [pii]
AID - 1203 [pii]
AID - 10.1186/s13098-023-01203-w [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2024 Jan 9;16(1):9. doi: 10.1186/s13098-023-01203-w.