PMID- 38191598
OWN - NLM
STAT- MEDLINE
DCOM- 20240110
LR  - 20240202
IS  - 2399-3642 (Electronic)
IS  - 2399-3642 (Linking)
VI  - 7
IP  - 1
DP  - 2024 Jan 8
TI  - Single-cell transcriptomic analyses of tumor microenvironment and molecular 
      reprograming landscape of metastatic laryngeal squamous cell carcinoma.
PG  - 63
LID - 10.1038/s42003-024-05765-x [doi]
LID - 63
AB  - Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with a high 
      probability of metastasis. The tumor microenvironment (TME) plays a critical role 
      in cancer metastasis. To gain insights into the TME of LSCC, we conducted 
      single-cell RNA-seq (scRNA-seq) on samples collected from LSCC patients with or 
      without lymphatic metastasis. The stem and immune cell signatures in LSCC suggest 
      their roles in tumor invasion and metastasis. Infiltration of a large number of 
      regulatory T cells, dysplastic plasma cells, and macrophages that are at the 
      early development stage in the cancerous tissue indicates an immunosuppressive 
      state. Abundant neutrophils detected at the cancer margins reflect the 
      inflammatory microenvironment. In addition to dynamic ligand-receptor 
      interactions between the stromal and myeloid cells, the enhanced autophagy in 
      endothelial cells and fibroblasts implies a role in nutrient supply. Taken 
      together, the comprehensive atlas of LSCC obtained allowed us to identify a 
      complex yet unique TME of LSCC, which may help identify potential diagnostic 
      biomarkers and therapeutic targets for LSCC.
CI  - (c) 2024. The Author(s).
FAU - Sun, Yuanyuan
AU  - Sun Y
AUID- ORCID: 0000-0003-2881-8712
AD  - Department of Medical Genetics, China Medical University, Shenyang, 110122, 
      China.
FAU - Chen, Sheng
AU  - Chen S
AD  - Department of Laboratory Animal Science, China Medical University, Shenyang, 
      110122, China.
FAU - Lu, Yongping
AU  - Lu Y
AD  - NHC Key Laboratory of Reproductive Health and Medical Genetics, Shenyang, 110122, 
      China.
FAU - Xu, Zhenming
AU  - Xu Z
AUID- ORCID: 0009-0000-4998-2824
AD  - Department of Otolaryngology, the Fourth People's Hospital of Shenyang City, 
      Shenyang, 110031, China. zhenmingxu@cmu.edu.cn.
FAU - Fu, Weineng
AU  - Fu W
AUID- ORCID: 0000-0002-0599-1021
AD  - Department of Medical Genetics, China Medical University, Shenyang, 110122, 
      China. wnfu@cmu.edu.cn.
FAU - Yan, Wei
AU  - Yan W
AUID- ORCID: 0000-0001-9569-9026
AD  - The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 
      Torrance, CA, 90502, USA. wei.yan@lundquist.org.
AD  - Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 
      90095, USA. wei.yan@lundquist.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240108
PL  - England
TA  - Commun Biol
JT  - Communications biology
JID - 101719179
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
MH  - *Endothelial Cells
MH  - Tumor Microenvironment/genetics
MH  - *Head and Neck Neoplasms
MH  - Gene Expression Profiling
PMC - PMC10774275
COIS- The authors declare no competing interests.
EDAT- 2024/01/09 00:42
MHDA- 2024/01/10 06:41
PMCR- 2024/01/08
CRDT- 2024/01/08 23:49
PHST- 2022/12/15 00:00 [received]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/01/10 06:41 [medline]
PHST- 2024/01/09 00:42 [pubmed]
PHST- 2024/01/08 23:49 [entrez]
PHST- 2024/01/08 00:00 [pmc-release]
AID - 10.1038/s42003-024-05765-x [pii]
AID - 5765 [pii]
AID - 10.1038/s42003-024-05765-x [doi]
PST - epublish
SO  - Commun Biol. 2024 Jan 8;7(1):63. doi: 10.1038/s42003-024-05765-x.