PMID- 38191745
OWN - NLM
STAT- MEDLINE
DCOM- 20240110
LR  - 20240110
IS  - 1435-2451 (Electronic)
IS  - 1435-2443 (Linking)
VI  - 409
IP  - 1
DP  - 2024 Jan 8
TI  - Prognostic significance of socioeconomic deprivation in patients with colorectal 
      liver metastasis undergoing liver resection: a retrospective cohort study.
PG  - 31
LID - 10.1007/s00423-023-03220-9 [doi]
AB  - AIMS: To evaluate the effect of socioeconomic deprivation on overall survival 
      (OS) in patients undergoing liver resection for colorectal liver metastasis 
      (CRLM). METHODS: The STROCSS guideline for observational studies was followed to 
      conduct a single-centre retrospective cohort study. All consecutive patients 
      undergoing resection of CRLM between 2013 and 2021 were considered eligible for 
      inclusion. The Welsh Index of Multiple Deprivation (WIMD) rank was used to 
      determine socioeconomic deprivation status of each patient. Prognostic 
      significance of socioeconomic deprivation was determined by Kaplan-Meier survival 
      statistics and stepwise Cox proportional-hazards regression model. RESULTS: A 
      total of 455 patients were eligible for inclusion; 237 patients were classed as 
      least socioeconomically deprived and 218 patients as most socioeconomically 
      deprived. Kaplan-Meier survival statistics showed that socioeconomic deprivation 
      was associated with significantly lower probability of overall survival (HR: 
      1.55, 95% CI 1.23-1.95; logrank test: P = 0.0001). The stepwise Cox 
      proportional-hazards regression analysis identified socioeconomic deprivation as 
      predictor of OS (HR: 1.56, P = 0.0003) alongside the following variables: ASA 
      status 1 (HR: 0.43, P = 0.0349), presence of extrahepatic disease (HR: 1.51, 
      P = 0.0075), number of tumours (HR: 1.07, P = 0.0221), size of largest tumour 
      (HR: 1.01, P = 0.0003), extended hemihepatectomy (HR: 3.24, P = 0.0018) and 
      absence of recurrence (HR: 0.55, P < 0.0001). CONCLUSIONS: Socioeconomic 
      deprivation reduces the probability of long-term overall survival following liver 
      resection in patients with CRLM. This should be taken into account at different 
      levels of health care planning for management of patients with CRLM including 
      preoperative risk assessment, health care need assessment and allocation of 
      resources.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Hajibandeh, Shahab
AU  - Hajibandeh S
AD  - Cardiff Liver Unit, University Hospital of Wales, Cardiff & Vale NHS Trust, 
      Cardiff, CF14 4XW, UK. Shahab_hajibandeh@yahoo.com.
FAU - Scarpa, Emanuele
AU  - Scarpa E
AD  - Cardiff Liver Unit, University Hospital of Wales, Cardiff & Vale NHS Trust, 
      Cardiff, CF14 4XW, UK.
FAU - Kaur, Namratha
AU  - Kaur N
AD  - Cardiff Liver Unit, University Hospital of Wales, Cardiff & Vale NHS Trust, 
      Cardiff, CF14 4XW, UK.
FAU - Alessandri, Giorgio
AU  - Alessandri G
AD  - Cardiff Liver Unit, University Hospital of Wales, Cardiff & Vale NHS Trust, 
      Cardiff, CF14 4XW, UK.
FAU - Kumar, Nagappan
AU  - Kumar N
AD  - Cardiff Liver Unit, University Hospital of Wales, Cardiff & Vale NHS Trust, 
      Cardiff, CF14 4XW, UK.
LA  - eng
PT  - Journal Article
DEP - 20240108
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Liver Neoplasms/surgery
MH  - Socioeconomic Factors
MH  - *Colorectal Neoplasms/surgery
OTO - NOTNLM
OT  - Colorectal liver metastases
OT  - Liver resection
OT  - Socioeconomic deprivation
OT  - Survival
EDAT- 2024/01/09 00:42
MHDA- 2024/01/10 06:41
CRDT- 2024/01/08 23:56
PHST- 2023/07/10 00:00 [received]
PHST- 2023/12/29 00:00 [accepted]
PHST- 2024/01/10 06:41 [medline]
PHST- 2024/01/09 00:42 [pubmed]
PHST- 2024/01/08 23:56 [entrez]
AID - 10.1007/s00423-023-03220-9 [pii]
AID - 10.1007/s00423-023-03220-9 [doi]
PST - epublish
SO  - Langenbecks Arch Surg. 2024 Jan 8;409(1):31. doi: 10.1007/s00423-023-03220-9.