PMID- 38193459
OWN - NLM
STAT- Publisher
LR  - 20240119
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
DP  - 2024 Jan 9
TI  - Association between PRKG1 gene and gene-environment interactions with pediatric 
      asthma.
PG  - 1-8
LID - 10.1080/02770903.2024.2303763 [doi]
AB  - OBJECTIVE: To investigate the relationship between single nucleotide 
      polymorphisms (SNPs) of cGMP-dependent protein kinase I (PRKG1) gene and 
      gene-environment interactions with bronchial asthma in children. METHODS: 109 
      asthma patients and 158 healthy controls from the General Hospital of Northern 
      Theater Command were enrolled, based case-control study. The iMLDR(R) multiple SNP 
      typing technique was applied to detect the genotypes of rs7903366, rs7081864, 
      rs7070958 and rs7897633 in PRKG1 gene. The percentage of eosinophils (EOS%) in 
      peripheral blood and serum immunoglobulin E (IgE) in the case group were also 
      measured. Gene-environment interactions were examined using the generalized 
      multi-factor dimensionality reduction (GMDR) method. RESULTS: There were 
      polymorphisms in four SNPs of PRKG1 gene in the case and control groups. The 
      genotype and allele frequencies distribution of rs7897633 demonstrated 
      statistical significance (p < 0.05). There were no statistically significant 
      differences in EOS% and IgE among genotypes at the four SNPs of PRKG1 gene 
      (p > 0.05). The haplotypes CAGA and TGAC presented significant association with 
      asthma risk (p < 0.05). The four-factor model indicated a potential 
      gene-environment interaction in rs7897633, allergen exposure, residence, and 
      environmental tobacco smoke (ETS) exposure (p < 0.05). CONCLUSIONS: The rs7897633 
      in PRKG1 gene was associated with susceptibility to childhood asthma, and C 
      allele is a protective factor. The haplotype CAGA had a protective effect against 
      asthma risk and TGAC was linked to the high risk of developing asthma. Moreover, 
      the interaction of rs7897633, allergen exposure, residence, and ETS exposure 
      conferred susceptibility to childhood asthma.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Neonatology, General Hospital of Northern Theater Command, 
      Shenyang, P.R. China.
AD  - Post-graduate College, China Medical University, Shenyang, P.R. China.
FAU - Wei, Bing
AU  - Wei B
AUID- ORCID: 0000-0002-5549-6694
AD  - Department of Neonatology, General Hospital of Northern Theater Command, 
      Shenyang, P.R. China.
FAU - Zhang, Yuxuan
AU  - Zhang Y
AD  - Department of Neonatology, General Hospital of Northern Theater Command, 
      Shenyang, P.R. China.
FAU - You, Yuan
AU  - You Y
AD  - Department of Neonatology, General Hospital of Northern Theater Command, 
      Shenyang, P.R. China.
FAU - Zhi, Yanjie
AU  - Zhi Y
AD  - Department of Neonatology, General Hospital of Northern Theater Command, 
      Shenyang, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20240109
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
SB  - IM
OTO - NOTNLM
OT  - PRKG1
OT  - asthma
OT  - children
OT  - interaction
OT  - polymorphism
EDAT- 2024/01/09 13:44
MHDA- 2024/01/09 13:44
CRDT- 2024/01/09 08:53
PHST- 2024/01/09 13:44 [pubmed]
PHST- 2024/01/09 13:44 [medline]
PHST- 2024/01/09 08:53 [entrez]
AID - 10.1080/02770903.2024.2303763 [doi]
PST - aheadofprint
SO  - J Asthma. 2024 Jan 9:1-8. doi: 10.1080/02770903.2024.2303763.