PMID- 38193461
OWN - NLM
STAT- MEDLINE
DCOM- 20240228
LR  - 20240419
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 40
IP  - 3
DP  - 2024 Mar
TI  - The two different profiles in heart failure with preserved ejection fraction and 
      type 2 diabetes mellitus: ischemic and diabetic.
PG  - 359-366
LID - 10.1080/03007995.2024.2303089 [doi]
AB  - OBJECTIVE: Two profiles of patients with heart failure with preserved ejection 
      fraction (HFpEF) and type 2 diabetes mellitus (T2DM) can be discerned: those with 
      ischemic and those with diabetic cardiomyopathy (DMC). We aim to analyze clinical 
      differences and prognosis between patients of these two profiles. MATERIAL AND 
      METHODS: This cohort study analyzes data from the Spanish Heart Failure Registry, 
      a multicenter, prospective registry that enrolled patients admitted for 
      decompensated heart failure and followed them for one year. Three groups were 
      created according to the presence of T2DM and heart disease depending on the 
      etiology (ischemic when coronary artery disease was present, or DMC when no 
      coronary, valvular, or congenital heart disease; no hypertension; nor 
      infiltrative cardiovascular disease observed on an endomyocardial biopsy). The 
      groups and outcomes were compared. RESULTS: A total of 466 patients were 
      analyzed. Group 1 (n = 210) included patients with ischemic etiology and T2DM. 
      Group 2 (n = 112) included patients with DMC etiology and T2DM. Group 3 
      (n = 144), a control group, included patients with ischemic etiology and without 
      T2DM. Group 1 had more hypertension and dyslipidemia; group 2 had more atrial 
      fibrillation (AF) and higher body mass index; group 3 had more chronic kidney 
      disease and were older. In the regression analysis, group 3 had a better 
      prognosis than group 1 (reference group) for cardiovascular mortality and HF 
      readmissions (HR 0.44;95%CI 0.2-1; p = .049). CONCLUSIONS: Patients with T2DM and 
      HFpEF, who had the poorest prognosis, were of two different profiles: either 
      ischemic or DMC etiology. The first had a higher burden of cardiovascular disease 
      and inflammation whereas the second had a higher prevalence of obesity and AF. 
      The first had a slightly poorer prognosis than the second, though this finding 
      was not significant.
FAU - Arevalo Lorido, Jose Carlos
AU  - Arevalo Lorido JC
AUID- ORCID: 0000-0002-2654-9339
AD  - Internal Medicine Department, University Hospital of Badajoz, Badajoz, Spain.
FAU - Carretero Gomez, Juana
AU  - Carretero Gomez J
AD  - Internal Medicine Department, University Hospital of Badajoz, Badajoz, Spain.
FAU - Conde Martel, Alicia
AU  - Conde Martel A
AD  - Internal Medicine Department, Dr. Negrin University Hospital of Gran Canaria, Las 
      Palmas de Gran Canaria, Spain.
FAU - Aramburu Bodas, Oscar
AU  - Aramburu Bodas O
AD  - Internal Medicine Department, Virgen Macarena University Hospital, Sevilla, 
      Spain.
FAU - Trullas, Joan Carles
AU  - Trullas JC
AD  - Internal Medicine Department, Olot and Garrotxa Regional Hospital, Olot, Girona, 
      Spain.
AD  - Tissue Repair and Regeneration Laboratory (TR2Lab), School of Medicine, 
      University of Vic-Central University of Catalonia, Vic, Barcelona, Spain.
FAU - Carrasco Sanchez, Francisco Javier
AU  - Carrasco Sanchez FJ
AUID- ORCID: 0000-0002-9275-7056
AD  - Internal Medicine Department, Juan Ramon Jimenez University Hospital, Huelva, 
      Spain.
FAU - Manzano Espinosa, Luis
AU  - Manzano Espinosa L
AD  - Internal Medicine Department, Ramon y Cajal University Hospital, Madrid, Spain.
FAU - Cerqueiro Gonzalez, Jose Manuel
AU  - Cerqueiro Gonzalez JM
AD  - Internal Medicine Department, Lucus Augusti University Hospital, Lugo, Spain.
FAU - Moreno Garcia, Carmen
AU  - Moreno Garcia C
AD  - Internal Medicine Department, Manises Hospital, Manises, Valencia, Spain.
FAU - Casado Cerrada, Jesus
AU  - Casado Cerrada J
AD  - Internal Medicine Department, University Hospital of Getafe, Getafe, Madrid, 
      Spain.
FAU - Montero Perez-Barquero, Manuel
AU  - Montero Perez-Barquero M
AD  - Internal Medicine Department, IMIBIC Reina Sofia University Hospital, Cordoba, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20240119
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - Humans
MH  - *Atrial Fibrillation
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Heart Failure
MH  - *Hypertension
MH  - Prognosis
MH  - Stroke Volume
MH  - Multicenter Studies as Topic
MH  - Registries
OTO - NOTNLM
OT  - Heart failure preserved ejection fraction
OT  - coronary artery disease
OT  - diabetic cardiomyopathy
OT  - type 2 diabetes mellitus
EDAT- 2024/01/09 13:43
MHDA- 2024/02/28 06:45
CRDT- 2024/01/09 08:53
PHST- 2024/02/28 06:45 [medline]
PHST- 2024/01/09 13:43 [pubmed]
PHST- 2024/01/09 08:53 [entrez]
AID - 10.1080/03007995.2024.2303089 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2024 Mar;40(3):359-366. doi: 10.1080/03007995.2024.2303089. 
      Epub 2024 Jan 19.