PMID- 38195327
OWN - NLM
STAT- MEDLINE
DCOM- 20240227
LR  - 20240227
IS  - 1943-4693 (Electronic)
IS  - 0027-9684 (Linking)
VI  - 116
IP  - 1
DP  - 2024 Feb
TI  - Role of novel biomarker monocyte chemo-attractant protein-1 in early diagnosis & 
      predicting progression of diabetic kidney disease: A comprehensive review.
PG  - 33-44
LID - S0027-9684(23)00154-2 [pii]
LID - 10.1016/j.jnma.2023.12.001 [doi]
AB  - Diabetic kidney disease (DKD) is the most devastating complication of diabetes 
      mellitus. Identification of patients at the early stages of progression may 
      reduce the disease burden. The limitation of conventional markers such as serum 
      creatinine and proteinuria intensify the need for novel biomarkers. The 
      traditional paradigm of DKD pathogenesis has expanded to the activation of the 
      immune system and inflammatory pathways. Monocyte chemo-attractant protein-1 
      (MCP-1) is extensively studied, as a key inflammatory mediator that modulates the 
      development of DKD. Recent evidence supports the diagnostic role of MCP-1 in 
      patients with or without proteinuria in DKD, as well as a significant role in the 
      early prediction and risk stratification of DKD. In this review, we will 
      summarize and update present evidence for MCP-1 for diagnostic ability and 
      predicting the progression of DKD.
CI  - Copyright (c) 2023 National Medical Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Swaminathan, Shilna Muttickal
AU  - Swaminathan SM
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Rao, Indu Ramachandra
AU  - Rao IR
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Bhojaraja, Mohan V
AU  - Bhojaraja MV
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Attur, Ravindra Prabhu
AU  - Attur RP
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Nagri, Shivashankara Kaniyoor
AU  - Nagri SK
AD  - Department of Medicine, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Rangaswamy, Dharshan
AU  - Rangaswamy D
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Shenoy, Srinivas Vinayak
AU  - Shenoy SV
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India.
FAU - Nagaraju, Shankar Prasad
AU  - Nagaraju SP
AD  - Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of 
      Higher Education, Manipal-576104, Karnataka, India. Electronic address: 
      shankarmmcmed@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240108
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Diabetic Nephropathies/diagnosis/etiology
MH  - Monocytes/metabolism
MH  - Proteinuria/complications
MH  - Biomarkers/metabolism
MH  - Early Diagnosis
MH  - *Diabetes Mellitus, Type 2/complications
OTO - NOTNLM
OT  - Albuminuria
OT  - Diabetic kidney disease
OT  - Immunity
OT  - Inflammation
OT  - MCP-1
EDAT- 2024/01/10 00:42
MHDA- 2024/02/27 06:45
CRDT- 2024/01/09 22:12
PHST- 2023/06/20 00:00 [received]
PHST- 2023/09/11 00:00 [revised]
PHST- 2023/12/03 00:00 [accepted]
PHST- 2024/02/27 06:45 [medline]
PHST- 2024/01/10 00:42 [pubmed]
PHST- 2024/01/09 22:12 [entrez]
AID - S0027-9684(23)00154-2 [pii]
AID - 10.1016/j.jnma.2023.12.001 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2024 Feb;116(1):33-44. doi: 10.1016/j.jnma.2023.12.001. Epub 
      2024 Jan 8.